2-nitro-3,4,5,6-tetrafluoro-β-oxobenzenepropanoic acid,ethyl ester

Base Information

Chemical Name:2-nitro-3,4,5,6-tetrafluoro-β-oxobenzenepropanoic acid,ethyl ester
CAS No.:103772-11-8
Molecular Formula:C₁₁H₇F₄NO₅
Molecular Weight:309.174
Hs Code.:

Synonyms:2-nitro-3,4,5,6-tetrafluoro-β-oxobenzenepropanoic acid,ethyl ester

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Chemical Property of 2-nitro-3,4,5,6-tetrafluoro-β-oxobenzenepropanoic acid,ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2-nitro-3,4,5,6-tetrafluoro-β-oxobenzenepropanoic acid,ethyl ester

There total 3 articles about 2-nitro-3,4,5,6-tetrafluoro-β-oxobenzenepropanoic acid,ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

: 103772-11-8
2-nitro-3,4,5,6-tetrafluoro-β-oxobenzenepropanoic acid,ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / H₂SO₄, 90percent HNO₃ / Ambient temperature

2: 1.) (COCl)2 / 1.) H₂CCl₂, DMF

With oxalyl dichloride; sulfuric acid; nitric acid;
DOI:10.1021/jm00398a003

Reference yield:

: 16583-08-7
2,3,4,5-tetrafluoro-6-nitrobenzoic acid

: 103772-11-8
2-nitro-3,4,5,6-tetrafluoro-β-oxobenzenepropanoic acid,ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 16 h

2: 1.) n-BuLi, dipyridyl / 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h

With n-butyllithium; dipyridyl; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm00107a039

Reference yield:

: 1071-46-1
hydrogen ethyl malonate

: 103772-10-7
2,3,4,5-tetrafluoro-6-nitro-benzoyl chloride

: 103772-11-8
2-nitro-3,4,5,6-tetrafluoro-β-oxobenzenepropanoic acid,ethyl ester

Guidance literature:: With n-butyllithium; dipyridyl; Yield given. Multistep reaction; 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h;
DOI:10.1021/jm00107a039