1-(4-(5-(3-(2-oxo-1-phenylcyclohexyl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3 - carboxylic acid

Base Information

Chemical Name:1-(4-(5-(3-(2-oxo-1-phenylcyclohexyl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3 - carboxylic acid
CAS No.:1356465-19-4
Molecular Formula:C₂₈H₃₁N₃O₄
Molecular Weight:473.572
Hs Code.:

Synonyms:1-(4-(5-(3-(2-oxo-1-phenylcyclohexyl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3 - carboxylic acid

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Chemical Property of 1-(4-(5-(3-(2-oxo-1-phenylcyclohexyl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3 - carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(4-(5-(3-(2-oxo-1-phenylcyclohexyl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3 - carboxylic acid

There total 11 articles about 1-(4-(5-(3-(2-oxo-1-phenylcyclohexyl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3 - carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356465-29-6
tert-butyl 1-(4-(5-(3-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

: 1356465-19-4
1-(4-(5-(3-(2-oxo-1-phenylcyclohexyl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3 - carboxylic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 7h;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1356465-19-4
1-(4-(5-(3-(2-oxo-1-phenylcyclohexyl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3 - carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / dichloromethane; methanol / 1 h / 20 °C

1.2: 18 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / 1,2-dichloro-ethane / 0 - 20 °C

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / tert-butyl alcohol / 7 h / 20 °C / Reflux

4.1: diisopropyl-carbodiimide / acetonitrile / 1 h / 20 °C

4.2: 18 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 7 h / 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropyl-carbodiimide; dmap; In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;

Reference yield:

: 7079-07-4
2-allyl-2-phenylcyclohexan-1-one

: 1356465-19-4
1-(4-(5-(3-(2-oxo-1-phenylcyclohexyl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3 - carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / benzene / 16.5 h / Reflux

2.1: sodium periodate / osmium(VIII) oxide / water; tert-butyl alcohol / 3 h

3.1: tetrahydrofuran / 18 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol / 3.5 h / 1292.9 Torr

5.1: sodium hydroxide; methanol / 4 h / 20 °C

6.1: diisopropyl-carbodiimide / acetonitrile / 1 h / 20 °C

6.2: 18 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 7 h / 20 °C

With hydrogenchloride; methanol; sodium periodate; hydrogen; toluene-4-sulfonic acid; sodium hydroxide; diisopropyl-carbodiimide; osmium(VIII) oxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile; tert-butyl alcohol; benzene;