tert-butyl 1-(4-(5-(3-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Base Information

Chemical Name:tert-butyl 1-(4-(5-(3-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate
CAS No.:1356465-29-6
Molecular Formula:C₃₄H₄₃N₃O₅
Molecular Weight:573.733
Hs Code.:

Synonyms:tert-butyl 1-(4-(5-(3-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 1-(4-(5-(3-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 1-(4-(5-(3-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

There total 13 articles about tert-butyl 1-(4-(5-(3-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1236144-54-9,1236148-77-8
(Z)-tert-butyl 1-(4-(N-hydroxycarbamimidoyl)benzyl)azetidine-3-carboxylate

: 1356465-27-4
4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoic acid

: 1356465-29-6
tert-butyl 1-(4-(5-(3-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Guidance literature:: (Z)-tert-butyl 1-(4-(N-hydroxycarbamimidoyl)benzyl)azetidine-3-carboxylate; 4-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)butanoic acid; With diisopropyl-carbodiimide; In acetonitrile; at 20 ℃; for 1h;

With tetrabutyl ammonium fluoride; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1356465-29-6
tert-butyl 1-(4-(5-(3-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / dichloromethane; methanol / 1 h / 20 °C

1.2: 18 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / 1,2-dichloro-ethane / 0 - 20 °C

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / tert-butyl alcohol / 7 h / 20 °C / Reflux

4.1: diisopropyl-carbodiimide / acetonitrile / 1 h / 20 °C

4.2: 18 h / 20 °C

With hydroxylamine hydrochloride; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropyl-carbodiimide; dmap; In methanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;

Reference yield:

: 7079-07-4
2-allyl-2-phenylcyclohexan-1-one

: 1356465-29-6
tert-butyl 1-(4-(5-(3-(6-phenyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / benzene / 16.5 h / Reflux

2.1: sodium periodate / osmium(VIII) oxide / water; tert-butyl alcohol / 3 h

3.1: tetrahydrofuran / 18 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol / 3.5 h / 1292.9 Torr

5.1: sodium hydroxide; methanol / 4 h / 20 °C

6.1: diisopropyl-carbodiimide / acetonitrile / 1 h / 20 °C

6.2: 18 h / 20 °C

With methanol; sodium periodate; hydrogen; toluene-4-sulfonic acid; sodium hydroxide; diisopropyl-carbodiimide; osmium(VIII) oxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; acetonitrile; tert-butyl alcohol; benzene;