2-[3-(1-carboxy-cyclopropylamino)-phenyl]-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid

Base Information

Chemical Name:2-[3-(1-carboxy-cyclopropylamino)-phenyl]-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid
CAS No.:1373544-48-9
Molecular Formula:C₂₂H₂₃ClN₂O₄
Molecular Weight:414.889
Hs Code.:

Synonyms:2-[3-(1-carboxy-cyclopropylamino)-phenyl]-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid

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Chemical Property of 2-[3-(1-carboxy-cyclopropylamino)-phenyl]-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid

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Technology Process of 2-[3-(1-carboxy-cyclopropylamino)-phenyl]-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid

There total 3 articles about 2-[3-(1-carboxy-cyclopropylamino)-phenyl]-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.5%

: 22059-21-8
aminocyclopropane-1-carboxylic acid

: 1373546-27-0
2-(3-bromo-phenyl)-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid methyl ester

: 1373544-48-9
2-[3-(1-carboxy-cyclopropylamino)-phenyl]-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid

Guidance literature:: aminocyclopropane-1-carboxylic acid; 2-(3-bromo-phenyl)-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid methyl ester; With potassium carbonate; copper(l) iodide; In dimethyl sulfoxide; at 120 ℃; for 16h;

With water; ammonium chloride; In dimethyl sulfoxide; ethyl acetate; at 20 ℃;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1373544-48-9
2-[3-(1-carboxy-cyclopropylamino)-phenyl]-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ytterbium(III) triflate / acetonitrile / 18 h / 85 °C / sealed tube

2.1: potassium carbonate / copper(l) iodide / dimethyl sulfoxide / 16 h / 120 °C

2.2: 20 °C

With potassium carbonate; copper(l) iodide; ytterbium(III) triflate; In dimethyl sulfoxide; acetonitrile;

Reference yield:

: 5202-89-1
4-chlorobenzenesulfonyl chloride

: 1373544-48-9
2-[3-(1-carboxy-cyclopropylamino)-phenyl]-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ytterbium(III) triflate / acetonitrile / 18 h / 85 °C / sealed tube

2.1: potassium carbonate / copper(l) iodide / dimethyl sulfoxide / 16 h / 120 °C

2.2: 20 °C

With potassium carbonate; copper(l) iodide; ytterbium(III) triflate; In dimethyl sulfoxide; acetonitrile;