4,4-dimethyl-2-(6-benzyloxy-2-methoxy-4,5-(methylenedioxy)phenyl)-2-oxazoline

Base Information

Chemical Name:4,4-dimethyl-2-(6-benzyloxy-2-methoxy-4,5-(methylenedioxy)phenyl)-2-oxazoline
CAS No.:173424-92-5
Molecular Formula:C₂₀H₂₁NO₅
Molecular Weight:355.39
Hs Code.:

Synonyms:4,4-dimethyl-2-(6-benzyloxy-2-methoxy-4,5-(methylenedioxy)phenyl)-2-oxazoline

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Chemical Property of 4,4-dimethyl-2-(6-benzyloxy-2-methoxy-4,5-(methylenedioxy)phenyl)-2-oxazoline

Chemical Property:

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Technology Process of 4,4-dimethyl-2-(6-benzyloxy-2-methoxy-4,5-(methylenedioxy)phenyl)-2-oxazoline

There total 4 articles about 4,4-dimethyl-2-(6-benzyloxy-2-methoxy-4,5-(methylenedioxy)phenyl)-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 100-39-0
benzyl bromide

: 173424-91-4
4,4-dimethyl-2-(6-hydroxy-2-methoxy-4,5-(methylenedioxy)phenyl)-2-oxazoline

: 173424-92-5
4,4-dimethyl-2-(6-benzyloxy-2-methoxy-4,5-(methylenedioxy)phenyl)-2-oxazoline

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; for 8h; Ambient temperature;
DOI:10.1021/jo951474x

Reference yield:

6-bromopiperonylic acid: 60546-62-5
6-bromopiperonylic acid

: 173424-92-5
4,4-dimethyl-2-(6-benzyloxy-2-methoxy-4,5-(methylenedioxy)phenyl)-2-oxazoline

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaOMe, 2.) Cu powder / 2) reflux, 18 h

2: 1.) C₂O₂Cl₂, 3.) SO₂Cl₂

3: 1.) n-BuLi, 2.) bis(trimethylsilyl)peroxide, 3.) HCl / 1) THF, hexane, -78 deg C, 30 min; 2) THF, hexane, rt, overnight; 3) MeOH, rt, 30 min

4: 92 percent / KOH / dimethylsulfoxide / 8 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; n-butyllithium; sulfuryl dichloride; oxalyl dichloride; bis-trimethylsilanyl peroxide; sodium methylate; copper; In dimethyl sulfoxide;
DOI:10.1021/jo951474x

Reference yield:

: 7168-93-6
6-methoxy-benzo[1,3]dioxole-5-carboxylic acid

: 173424-92-5
4,4-dimethyl-2-(6-benzyloxy-2-methoxy-4,5-(methylenedioxy)phenyl)-2-oxazoline

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) C₂O₂Cl₂, 3.) SO₂Cl₂

2: 1.) n-BuLi, 2.) bis(trimethylsilyl)peroxide, 3.) HCl / 1) THF, hexane, -78 deg C, 30 min; 2) THF, hexane, rt, overnight; 3) MeOH, rt, 30 min

3: 92 percent / KOH / dimethylsulfoxide / 8 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; n-butyllithium; sulfuryl dichloride; oxalyl dichloride; bis-trimethylsilanyl peroxide; In dimethyl sulfoxide;
DOI:10.1021/jo951474x