7168-93-6Relevant academic research and scientific papers
1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO[4,5] DECANE DERIVATIVES
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, (2008/06/13)
Heterocyclic compounds of Formula I: STR1 in which n is 2, 3, 4, 5 or 6; t is 1, 2, 3 or 4; u is 0 or 1 (provided that t is not 1 when u is 0); X is O or N(R 4); Y and Z are independently C(O), C(S) or CH 2 (provided that Y and Z are not both CH 2); R 1, R. sup.2, R 3, and R 4 are as defined in the specification; and their pharmaceutically acceptable salts and N-oxides, formulations containing them, their uses as therapeutic agents, and their synthesis.
An oxazoline-mediated synthesis of the pyrrolophenanthridine alkaloids and some novel derivatives
Hutchings, Richard H.,Meyers
, p. 1004 - 1013 (2007/10/03)
An unsymmetrical biaryl coupling between the Grignard of N-benzyl-7-bromoindoline 25 and the appropriately substituted (o-methoxyaryl)oxazoline 15 leads to an intermediate biaryl which can be elaborated in one step to the 1H-pyrrolo[3,2,1-de]phenanthridine ring system. This simple two-step sequence provides general access to the pyrrolophenanthridine alkaloids 2-6.
NEW FUROFURANO LIGNANS FROM JUSTICIA SIMPLEX
Ghosal, Shibnath,Banerjee, Shanta,Jaiswal, Dinesh K.
, p. 332 - 334 (2007/10/02)
A new 3,7-dioxabicyclooctane lignan, named justisolin, and a new lignan O-glucoside, named simplexoside, were isolated from the whole plant of justicia simplex D.Don. (Acanthaceae), collected at fruiting.The structure of the free lignan was established as 2e-(3,4-methylenedioxy-6-hydroxy)-phenyl-6e-piperonyl-3,7-dioxabicyclooctane (1) and that of the glucoside as 2e-(3-methoxy-4-O-β-D-glucopyranosyl)-phenyl-6e-piperonyl-3,7-dioxabicyclooctane (2) on the basis of chemical transformation and spectral evidence.The biological functions of these and related lignans are appraised.Key Word Index - Justicia simplex; Acanthaceae; 3,7-dioxabicyclooctane lignan; justisolin; lignan O-glucoside; simplexoside; isolation; structure elucidation; biological function.
