Chemical Property of Docosanol
Chemical Property:
- Appearance/Colour:white powder
- Vapor Pressure:0.0226mmHg at 25°C
- Melting Point:65-72 °C(lit.)
- Refractive Index:1.47
- Boiling Point:375.9 °C at 760 mmHg
- PKA:15.20±0.10(Predicted)
- Flash Point:142.5 °C
- PSA：20.23000
- Density:0.839 g/cm3
- LogP:7.80060
- Storage Temp.:2-8°C
- Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly)
- Water Solubility.:Insoluble
- XLogP3:10.5
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:20
- Exact Mass:326.354866087
- Heavy Atom Count:23
- Complexity:190
- Purity/Quality:
-
99% *data from raw suppliers
1-Docosanol *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Chemical Classes:Other Classes -> Alcohols and Polyols, Other
- Canonical SMILES:CCCCCCCCCCCCCCCCCCCCCCO
- Recent ClinicalTrials:EDTA Eye Drops Compared to Abreva for Herpes Simplex Virus Eruptions
- Recent EU Clinical Trials:Etude de l’efficacité et de la tolérance, de l’injection intra prostatique de toxine botulique A, chez l’homme, dans le traitement de l’hyperplasie bénigne de prostate symptomatique.
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Uses
n-Docosanol is a binder and an emulsion stabilizer. It is also used to increase a formulation’s viscosity. This is a mixture of fatty alcohols. behenyl alcohol may be used for any number of purposes in a cosmetic formulation, including as an emollient, a binder, an emulsion stabilizer, or to increase a product’s viscosity. It may be derived either synthetically or from plants. 1-Docosanol works as a surfactant in cosmetics. 1-Docosanol cream has also been approved by the US Food and Drug Administration as a safe and effective topical treatment for herpes labialis
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Indications
Docosanol (Abreva) is a long-chain saturated alcohol
that is clinically effective against HSV. It has in vitro activity
against many enveloped viruses, including CMV,
influenzavirus, and respiratory syncytial virus.
Docosanol is not directly virucidal; instead, it blocks
the entry of the virion into the host cell by inhibiting the
fusion of the viral envelope with the host plasma membrane.
Because it does not affect viral replication or protein
production, it may be less susceptible to the development
of resistance than other antiviral drugs.
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Clinical Use
Docosanol cream is approved for the over-the-counter
treatment of herpes labialis. It shortens the duration of
symptoms of cold sores and fever blisters but does not
provide symptomatic relief.
