ethyl (2S)-2-[(4S)-4-(benzyloxycarbonylamino)-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

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Chemical Name:ethyl (2S)-2-[(4S)-4-(benzyloxycarbonylamino)-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate
CAS No.:197223-19-1
Molecular Formula:C₂₃H₃₂N₂O₈S
Molecular Weight:496.582
Hs Code.:

Synonyms:ethyl (2S)-2-[(4S)-4-(benzyloxycarbonylamino)-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

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Chemical Property of ethyl (2S)-2-[(4S)-4-(benzyloxycarbonylamino)-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

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Technology Process of ethyl (2S)-2-[(4S)-4-(benzyloxycarbonylamino)-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

There total 3 articles about ethyl (2S)-2-[(4S)-4-(benzyloxycarbonylamino)-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 15149-59-4
diethyl N-[α-methyl N-(benzyloxycarbonyl)-L-γ-glutamyl]-L-glutamate

: 197223-19-1
ethyl (2S)-2-[(4S)-4-(benzyloxycarbonylamino)-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; at 20 ℃; Heating;
DOI:10.1016/S0040-4020(97)00851-X

Reference yield:

: 5672-83-3
Z-L-GluOMe

: 197223-19-1
ethyl (2S)-2-[(4S)-4-(benzyloxycarbonylamino)-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -20 °C

2: 2.75 g / N-methylmorpholine / tetrahydrofuran / 1.67 h / -20 - 20 °C

3: 90 percent / Lawesson's reagent / tetrahydrofuran / 20 °C / Heating

With Lawessons reagent; 4-methyl-morpholine; In tetrahydrofuran; 1: Acylation / 2: Acylation / 3: thionation;
DOI:10.1016/S0040-4020(97)00851-X

Reference yield:

: 112127-59-0
(S)-2-Benzyloxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid methyl ester

: 197223-19-1
ethyl (2S)-2-[(4S)-4-(benzyloxycarbonylamino)-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 2.75 g / N-methylmorpholine / tetrahydrofuran / 1.67 h / -20 - 20 °C

2: 90 percent / Lawesson's reagent / tetrahydrofuran / 20 °C / Heating

With Lawessons reagent; 4-methyl-morpholine; In tetrahydrofuran; 1: Acylation / 2: thionation;
DOI:10.1016/S0040-4020(97)00851-X