N-(4-(3-chlorophenyl)-5-(2-fluorobenzoyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Base Information

Chemical Name:N-(4-(3-chlorophenyl)-5-(2-fluorobenzoyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
CAS No.:1361413-12-8
Molecular Formula:C₂₆H₂₀ClFN₂O₄S₂
Molecular Weight:543.039
Hs Code.:

Synonyms:N-(4-(3-chlorophenyl)-5-(2-fluorobenzoyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

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Chemical Property of N-(4-(3-chlorophenyl)-5-(2-fluorobenzoyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

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Technology Process of N-(4-(3-chlorophenyl)-5-(2-fluorobenzoyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

There total 10 articles about N-(4-(3-chlorophenyl)-5-(2-fluorobenzoyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 383135-47-5
2-[4-(ethanesulfonyl)phenyl]acetic acid

: 1361413-66-2
[2-amino-4-(3-chlorophenyl)-1,3-thiazol-5-yl](2-fluorophenyl)methanone

: 1361413-12-8
N-(4-(3-chlorophenyl)-5-(2-fluorobenzoyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2013.12.021

Reference yield:

: 445-27-2
2'-Fluoroacetophenone

: 1361413-12-8
N-(4-(3-chlorophenyl)-5-(2-fluorobenzoyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / diethyl ether / 0 - 20 °C

2: N,N-dimethyl-formamide / 0.67 h / 85 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 24 h / 20 °C / Inert atmosphere

With bromine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: ethyl 2-(4-(ethylsulfonyl)phenyl)acetate

: 1361413-12-8
N-(4-(3-chlorophenyl)-5-(2-fluorobenzoyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / ethanol / 20 °C

1.2: pH 1

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 24 h / 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; dichloromethane;