2-[4-(ethylsulfonyl)phenyl]-N-(4-{[(phenylmethyl)(propyl)amino]methyl}phenyl)acetamide

Base Information

Chemical Name:2-[4-(ethylsulfonyl)phenyl]-N-(4-{[(phenylmethyl)(propyl)amino]methyl}phenyl)acetamide
CAS No.:1508310-34-6
Molecular Formula:C₂₇H₃₂N₂O₃S
Molecular Weight:464.629
Hs Code.:

Synonyms:2-[4-(ethylsulfonyl)phenyl]-N-(4-{[(phenylmethyl)(propyl)amino]methyl}phenyl)acetamide

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Chemical Property of 2-[4-(ethylsulfonyl)phenyl]-N-(4-{[(phenylmethyl)(propyl)amino]methyl}phenyl)acetamide

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Technology Process of 2-[4-(ethylsulfonyl)phenyl]-N-(4-{[(phenylmethyl)(propyl)amino]methyl}phenyl)acetamide

There total 16 articles about 2-[4-(ethylsulfonyl)phenyl]-N-(4-{[(phenylmethyl)(propyl)amino]methyl}phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1508310-56-2
2-[4-(ethylsulfonyl)phenyl]-N-{4-[(propylamino)methyl]phenyl}acetamide

: 100-39-0
benzyl bromide

: 1508310-34-6
2-[4-(ethylsulfonyl)phenyl]-N-(4-{[(phenylmethyl)(propyl)amino]methyl}phenyl)acetamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 3h; Sealed tube; Heating;
DOI:10.1016/j.ejmech.2021.113704

Reference yield: 43.9%

: 1099073-00-3
[(4-aminophenyl)methyl](phenylmethyl)propylamine

: 383135-47-5
2-[4-(ethanesulfonyl)phenyl]acetic acid

: 1508310-34-6
2-[4-(ethylsulfonyl)phenyl]-N-(4-{[(phenylmethyl)(propyl)amino]methyl}phenyl)acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/ml4003875

Reference yield:

: N-[(4-nitrophenyl)methyl]-N-(phenylmethyl)-1-propanamine

: 1508310-34-6
2-[4-(ethylsulfonyl)phenyl]-N-(4-{[(phenylmethyl)(propyl)amino]methyl}phenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; iron / 72 h / 120 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With iron; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/ml4003875