{(E)-2-Isocyanato-3-(4-methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-allyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:{(E)-2-Isocyanato-3-(4-methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-allyl}-carbamic acid 2-trimethylsilanyl-ethyl ester
CAS No.:862263-47-6
Molecular Formula:C₂₅H₃₀N₂O₅Si
Molecular Weight:466.609
Hs Code.:

Synonyms:{(E)-2-Isocyanato-3-(4-methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-allyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of {(E)-2-Isocyanato-3-(4-methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-allyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of {(E)-2-Isocyanato-3-(4-methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-allyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

There total 15 articles about {(E)-2-Isocyanato-3-(4-methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-allyl}-carbamic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 862263-04-5
(E)-4-(4-Methoxy-phenyl)-2-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-3-(2-trimethylsilanyl-ethoxycarbonylamino)-but-3-enoic acid

: 862263-47-6
{(E)-2-Isocyanato-3-(4-methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-allyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With diphenylphosphoranyl azide; sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2005.05.077

Reference yield: 32.0%

: 862263-45-4
(E)-4-(4-Methoxy-phenyl)-2-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-3-(2-trimethylsilanyl-ethoxycarbonylamino)-but-3-enoic acid

: 862263-47-6
{(E)-2-Isocyanato-3-(4-methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-allyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With diphenylphosphoranyl azide; sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2005.05.077

Reference yield:

: 2227-57-8
3-(4-methoxyphenyl)propynoic acid

: 862263-47-6
{(E)-2-Isocyanato-3-(4-methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-allyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 96 percent / DCC; DMAP / CH₂Cl₂ / 12 h / -20 - 20 °C

2.1: n-Bu₃SnH / Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 0 °C

2.2: CuI / Pd(PPh₃)2Cl₂ / dimethylformamide / 6 h / 60 °C

3.1: 100 percent / TBAF / tetrahydrofuran / 7 h / 20 °C

4.1: 63 percent / diphenylphosphoryl azide; NaH / dimethylformamide / 3 h / 0 - 20 °C

5.1: 62 percent / pyridine / tetrahydrofuran / 12 h / 60 °C

6.1: 70 percent / MgBr₂*OEt₂ / diethyl ether / 5 h / 20 °C

7.1: 50 percent / diphenylphosphoryl azide; NaH / dimethylformamide / 2 h / 0 - 20 °C

With pyridine; dmap; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; sodium hydride; dicyclohexyl-carbodiimide; magnesium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 4.1: Curtius rearrangement / 7.1: Curtius rearrangement;
DOI:10.1016/j.tetlet.2005.05.077