[(E)-3-(4-Methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-(2-trimethylsilanyl-ethoxycarbonylamino)-allyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:[(E)-3-(4-Methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-(2-trimethylsilanyl-ethoxycarbonylamino)-allyl]-carbamic acid 2-trimethylsilanyl-ethyl ester
CAS No.:862263-06-7
Molecular Formula:C₃₀H₄₄N₂O₆Si₂
Molecular Weight:584.86
Hs Code.:

[(E)-3-(4-Methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-(2-trimethylsilanyl-ethoxycarbonylamino)-allyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

Synonyms:[(E)-3-(4-Methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-(2-trimethylsilanyl-ethoxycarbonylamino)-allyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of [(E)-3-(4-Methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-(2-trimethylsilanyl-ethoxycarbonylamino)-allyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of [(E)-3-(4-Methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-(2-trimethylsilanyl-ethoxycarbonylamino)-allyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

There total 16 articles about [(E)-3-(4-Methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-(2-trimethylsilanyl-ethoxycarbonylamino)-allyl]-carbamic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 862263-47-6
{(E)-2-Isocyanato-3-(4-methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-allyl}-carbamic acid 2-trimethylsilanyl-ethyl ester

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 862263-06-7
[(E)-3-(4-Methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-(2-trimethylsilanyl-ethoxycarbonylamino)-allyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With pyridine; In tetrahydrofuran; at 60 ℃; for 12h;
DOI:10.1016/j.tetlet.2005.05.077

Reference yield:

: 2227-57-8
3-(4-methoxyphenyl)propynoic acid

: 862263-06-7
[(E)-3-(4-Methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-(2-trimethylsilanyl-ethoxycarbonylamino)-allyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 96 percent / DCC; DMAP / CH₂Cl₂ / 12 h / -20 - 20 °C

2.1: n-Bu₃SnH / Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 0 °C

2.2: CuI / Pd(PPh₃)2Cl₂ / dimethylformamide / 6 h / 60 °C

3.1: 100 percent / TBAF / tetrahydrofuran / 7 h / 20 °C

4.1: 63 percent / diphenylphosphoryl azide; NaH / dimethylformamide / 3 h / 0 - 20 °C

5.1: 62 percent / pyridine / tetrahydrofuran / 12 h / 60 °C

6.1: 70 percent / MgBr₂*OEt₂ / diethyl ether / 5 h / 20 °C

7.1: 50 percent / diphenylphosphoryl azide; NaH / dimethylformamide / 2 h / 0 - 20 °C

8.1: 50 percent / pyridine / tetrahydrofuran / 12 h / 60 °C

With pyridine; dmap; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; sodium hydride; dicyclohexyl-carbodiimide; magnesium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 4.1: Curtius rearrangement / 7.1: Curtius rearrangement;
DOI:10.1016/j.tetlet.2005.05.077

Reference yield:

: 862262-88-2
(4-methoxy-phenyl)-propynoic acid methoxymethyl ester

: 862263-06-7
[(E)-3-(4-Methoxy-phenyl)-1-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-(2-trimethylsilanyl-ethoxycarbonylamino)-allyl]-carbamic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-Bu₃SnH / Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 0 °C

1.2: Br₂ / CH₂Cl₂ / 0.5 h / 0 °C

2.1: n-Bu₃SnH / Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 0 °C

2.2: CuI / Pd(PPh₃)2Cl₂ / dimethylformamide / 6 h / 60 °C

3.1: 100 percent / TBAF / tetrahydrofuran / 7 h / 20 °C

4.1: 63 percent / diphenylphosphoryl azide; NaH / dimethylformamide / 3 h / 0 - 20 °C

5.1: 62 percent / pyridine / tetrahydrofuran / 12 h / 60 °C

6.1: 70 percent / MgBr₂*OEt₂ / diethyl ether / 5 h / 20 °C

7.1: 50 percent / diphenylphosphoryl azide; NaH / dimethylformamide / 2 h / 0 - 20 °C

8.1: 50 percent / pyridine / tetrahydrofuran / 12 h / 60 °C

With pyridine; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; sodium hydride; magnesium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 4.1: Curtius rearrangement / 7.1: Curtius rearrangement;
DOI:10.1016/j.tetlet.2005.05.077