(S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionic acid methyl ester

Base Information

• Chemical Name: (S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionic acid methyl ester
• CAS No.: 234122-57-7
• Molecular Formula: C₂₀H₃₀N₂O₆
• Molecular Weight: 394.468
• Mol file: 234122-57-7.mol

Synonyms:(S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionic acid methyl ester

Chemical Property of (S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionic acid methyl ester

There total 5 articles about (S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

t-Boc-L-valine (13734-41-3) + methyl (S)-2-amino-3-(3-hydroxyphenyl)propanoate (167935-97-9) → (S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionic acid methyl ester (234122-57-7)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 25 ℃; for 3h;

Reference yield:

(S)-methyl 2-((benzyloxycarbonyl)amino)-3-(3-hydroxyphenyl)propanoate (234122-64-6) → (S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionic acid methyl ester (234122-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / H₂ / Pd/C / methanol / 12 h / 25 °C / 760.05 Torr

2: 78 percent / EDC; HOAt / CH₂Cl₂ / 3 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; dichloromethane; 1: Hydrogenolysis / 2: Acylation;

DOI:10.1021/ja994285v

Reference yield:

(Z)-methyl 2-((benzyloxycarbonyl)amino)-3-(3-hydroxyphenyl)acrylate (234122-56-6) → (S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionic acid methyl ester (234122-57-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / H₂ / [(S,S)-Et-DuP-Rh]⁺TfO^- / methanol / 96 h / 3102.97 Torr

2: 96 percent / H₂ / Pd/C / methanol / 12 h / 25 °C / 760.05 Torr

3: 78 percent / EDC; HOAt / CH₂Cl₂ / 3 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; (+)-1,2-bis((2S,5S)-2,5-diethylphospholano)benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; In methanol; dichloromethane; 1: stereoselective hydrogenation / 2: Hydrogenolysis / 3: Acylation;

DOI:10.1021/ja994285v

upstream raw materials:

t-Boc-L-valine

methyl (S)-2-amino-3-(3-hydroxyphenyl)propanoate

meta-hydroxybenzaldehyde

(S)-methyl 2-((benzyloxycarbonyl)amino)-3-(3-hydroxyphenyl)propanoate

Downstream raw materials:

(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester

(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester

(R)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester

(R)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(3-hydroxy-phenyl)-propionyl]-hexahydro-pyridazine-3-carboxylic acid (E)-4-iodo-but-3-enyl ester