3,4-dihydro-(3S)-isobutyl-6-(4-methoxyphenyl)-4-N-(4-nitrobenenesulfonyl)[1,4]oxazin-2-one

Base Information

Chemical Name:3,4-dihydro-(3S)-isobutyl-6-(4-methoxyphenyl)-4-N-(4-nitrobenenesulfonyl)[1,4]oxazin-2-one
CAS No.:585527-78-2
Molecular Formula:C₂₁H₂₂N₂O₇S
Molecular Weight:446.481
Hs Code.:

Synonyms:3,4-dihydro-(3S)-isobutyl-6-(4-methoxyphenyl)-4-N-(4-nitrobenenesulfonyl)[1,4]oxazin-2-one

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Chemical Property of 3,4-dihydro-(3S)-isobutyl-6-(4-methoxyphenyl)-4-N-(4-nitrobenenesulfonyl)[1,4]oxazin-2-one

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Technology Process of 3,4-dihydro-(3S)-isobutyl-6-(4-methoxyphenyl)-4-N-(4-nitrobenenesulfonyl)[1,4]oxazin-2-one

There total 3 articles about 3,4-dihydro-(3S)-isobutyl-6-(4-methoxyphenyl)-4-N-(4-nitrobenenesulfonyl)[1,4]oxazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 585527-73-7
N-(2-(4-methoxyphenyl)-2-oxoethyl)-N-(4-nitrobenzenesulfonyl)-L-leucine

: 585527-78-2
3,4-dihydro-(3S)-isobutyl-6-(4-methoxyphenyl)-4-N-(4-nitrobenenesulfonyl)[1,4]oxazin-2-one

Guidance literature:: With TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dichloromethane; at 25 ℃; for 14h;
DOI:10.1039/b212064j

Reference yield:

: 21691-53-2
L-leucine tert-butyl ester

: 585527-78-2
3,4-dihydro-(3S)-isobutyl-6-(4-methoxyphenyl)-4-N-(4-nitrobenenesulfonyl)[1,4]oxazin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / TEA / CH₂Cl₂ / 12 h / 25 °C

2: 95 percent / K₂CO₃ / acetonitrile / 5 h / 25 °C

3: 100 percent / TFA / CH₂Cl₂ / 1 h / 25 °C

4: 92 percent / PyBOP; TEA / CH₂Cl₂ / 14 h / 25 °C

With TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1039/b212064j

Reference yield:

: 585527-64-6
N-(4-nitrobenzenesulfonyl)-L-leucine tert-butyl ester

: 585527-78-2
3,4-dihydro-(3S)-isobutyl-6-(4-methoxyphenyl)-4-N-(4-nitrobenenesulfonyl)[1,4]oxazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / K₂CO₃ / acetonitrile / 5 h / 25 °C

2: 100 percent / TFA / CH₂Cl₂ / 1 h / 25 °C

3: 92 percent / PyBOP; TEA / CH₂Cl₂ / 14 h / 25 °C

With TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1039/b212064j