{3-[(4-{5-[(3-chloro-2-fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl}benzyl)amino]propyl}phosphonic acid

Base Information

Chemical Name:{3-[(4-{5-[(3-chloro-2-fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl}benzyl)amino]propyl}phosphonic acid
CAS No.:1609536-25-5
Molecular Formula:C₁₉H₂₀ClFN₃O₄PS
Molecular Weight:471.877
Hs Code.:

Synonyms:{3-[(4-{5-[(3-chloro-2-fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl}benzyl)amino]propyl}phosphonic acid

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Chemical Property of {3-[(4-{5-[(3-chloro-2-fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl}benzyl)amino]propyl}phosphonic acid

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Technology Process of {3-[(4-{5-[(3-chloro-2-fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl}benzyl)amino]propyl}phosphonic acid

There total 3 articles about {3-[(4-{5-[(3-chloro-2-fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl}benzyl)amino]propyl}phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13138-33-5
3-aminopropanephosphonic acid

: 1609537-11-2
4-{5-[(3-chloro-2-fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl}benzaldehyde

: 1609536-25-5
{3-[(4-{5-[(3-chloro-2-fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl}benzyl)amino]propyl}phosphonic acid

Guidance literature:: 2-amino-4'-methoxyacetophenone hydrochloride; With triethylamine; In dichloromethane; at 10 ℃; Large scale;

cinnamoyl chloride; In dichloromethane; at 25 ℃; for 3h; Large scale;

Reference yield:

: 58855-42-8
4-(hydroxymethyl)benzoic hydrazide

: 1609536-25-5
{3-[(4-{5-[(3-chloro-2-fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl}benzyl)amino]propyl}phosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / ethanol / 16 h / Reflux

2.1: sodium hydroxide / water / 16 h / 20 °C

3.1: periodic acid; pyridinium chlorochromate / acetonitrile / 1.25 h / 0 - 20 °C

4.1: tetra(n-butyl)ammonium hydroxide / methanol / 1 h / 50 °C

4.2: 3 h / 20 °C

With tetra(n-butyl)ammonium hydroxide; periodic acid; triethylamine; pyridinium chlorochromate; sodium hydroxide; In methanol; ethanol; water; acetonitrile;

Reference yield:

: 1609536-71-1
[4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl]methanol

: 1609536-25-5
{3-[(4-{5-[(3-chloro-2-fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl}benzyl)amino]propyl}phosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 16 h / 20 °C

2.1: periodic acid; pyridinium chlorochromate / acetonitrile / 1.25 h / 0 - 20 °C

3.1: tetra(n-butyl)ammonium hydroxide / methanol / 1 h / 50 °C

3.2: 3 h / 20 °C

With tetra(n-butyl)ammonium hydroxide; periodic acid; pyridinium chlorochromate; sodium hydroxide; In methanol; water; acetonitrile;