1,6-dimethyl-2-[4-(2-benzyloxyphenyl)-n-butanamido]methyl-3-benzyloxy-4(1H)-pyridinone

Base Information

Chemical Name:1,6-dimethyl-2-[4-(2-benzyloxyphenyl)-n-butanamido]methyl-3-benzyloxy-4(1H)-pyridinone
CAS No.:445290-50-6
Molecular Formula:C₃₂H₃₄N₂O₄
Molecular Weight:510.633
Hs Code.:

Synonyms:1,6-dimethyl-2-[4-(2-benzyloxyphenyl)-n-butanamido]methyl-3-benzyloxy-4(1H)-pyridinone

Suppliers and Price of 1,6-dimethyl-2-[4-(2-benzyloxyphenyl)-n-butanamido]methyl-3-benzyloxy-4(1H)-pyridinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,6-dimethyl-2-[4-(2-benzyloxyphenyl)-n-butanamido]methyl-3-benzyloxy-4(1H)-pyridinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,6-dimethyl-2-[4-(2-benzyloxyphenyl)-n-butanamido]methyl-3-benzyloxy-4(1H)-pyridinone

There total 5 articles about 1,6-dimethyl-2-[4-(2-benzyloxyphenyl)-n-butanamido]methyl-3-benzyloxy-4(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 401792-02-7
2-(aminomethyl)-1,6-dimethyl-3-(phenylmethoxy)-4(1H)-pyridinone

: 445290-41-5
N-[3-[(2-benzyloxyphenyl)-prop-1-yl]carboxy]succinimide

: 445290-50-6
1,6-dimethyl-2-[4-(2-benzyloxyphenyl)-n-butanamido]methyl-3-benzyloxy-4(1H)-pyridinone

Guidance literature:: In dichloromethane;
DOI:10.1211/0022357021778592

Reference yield:

: 100-39-0
benzyl bromide

: 445290-50-6
1,6-dimethyl-2-[4-(2-benzyloxyphenyl)-n-butanamido]methyl-3-benzyloxy-4(1H)-pyridinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / NaOH / H₂O; methanol

2.1: 90 percent / triphenylphosphine; CBr₄ / tetrahydrofuran; acetonitrile / 18 h / 20 °C

3.1: NaH / tetrahydrofuran; various solvent(s) / 20 °C

4.1: KOH / tetrahydrofuran; H₂O / 48 h / Heating

4.2: 25 percent / conc. HCl; H₂O / 4 h / pH 1 - 3 / Heating

5.1: 70 percent / 4-dimethylaminopyridine; dicyclohexyldicarbodiimide / CH₂Cl₂

6.1: 70 percent / CH₂Cl₂

With dmap; potassium hydroxide; sodium hydroxide; carbon tetrabromide; sodium hydride; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1211/0022357021778592

Reference yield:

: 107607-78-3
1-(benzyloxy)-2-(2-bromoethyl)benzene

: 445290-50-6
1,6-dimethyl-2-[4-(2-benzyloxyphenyl)-n-butanamido]methyl-3-benzyloxy-4(1H)-pyridinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran; various solvent(s) / 20 °C

2.1: KOH / tetrahydrofuran; H₂O / 48 h / Heating

2.2: 25 percent / conc. HCl; H₂O / 4 h / pH 1 - 3 / Heating

3.1: 70 percent / 4-dimethylaminopyridine; dicyclohexyldicarbodiimide / CH₂Cl₂

4.1: 70 percent / CH₂Cl₂

With dmap; potassium hydroxide; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1211/0022357021778592