benzyl ((1R,3S)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-inden-1-yl)methylcarbamate

Base Information

Chemical Name:benzyl ((1R,3S)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-inden-1-yl)methylcarbamate
CAS No.:1422045-80-4
Molecular Formula:C₂₄H₂₁Cl₂NO₂
Molecular Weight:426.342
Hs Code.:

Synonyms:benzyl ((1R,3S)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-inden-1-yl)methylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl ((1R,3S)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-inden-1-yl)methylcarbamate

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Technology Process of benzyl ((1R,3S)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-inden-1-yl)methylcarbamate

There total 6 articles about benzyl ((1R,3S)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-inden-1-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1422045-79-1
benzyl ((1R,3S)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-inden-1-yl)carbamate

: 74-88-4
methyl iodide

: 1422045-80-4
benzyl ((1R,3S)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-inden-1-yl)methylcarbamate

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tet.2012.12.044

Reference yield:

: 1422045-78-0
(1R,3S)-1-(benzyloxy)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-indene

: 1422045-80-4
benzyl ((1R,3S)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-inden-1-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / hexane / 40 h / -40 °C / Inert atmosphere

1.2: 12 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 12 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; sodium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2012.12.044

Reference yield:

: 95-50-1
1,2-dichloro-benzene

: 1422045-80-4
benzyl ((1R,3S)-3-(3,4-dichlorophenyl)-2,3-dihydro-1H-inden-1-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluorormethanesulfonic acid / 72 h / 0 - 20 °C / Inert atmosphere

2.1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; borane Ν,Ν-diethylaniline complex / toluene / 4 h / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 12 h / 0 - 20 °C / Inert atmosphere

4.1: sodium carbonate / hexane / 40 h / -40 °C / Inert atmosphere

4.2: 12 h / 20 °C

5.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 12 h / 0 - 20 °C / Inert atmosphere

With borane Ν,Ν-diethylaniline complex; trifluorormethanesulfonic acid; sodium hydride; sodium carbonate; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.tet.2012.12.044