3-(3-cyano-4-fluorophenyl)-5-[[5-[(2'-t-butylaminosulfonyl)phenyl]pyrid-2-yl]aminocarbonyl]-5-(methylsulfonylaminomethyl)isoxazoline

Base Information

Chemical Name:3-(3-cyano-4-fluorophenyl)-5-[[5-[(2'-t-butylaminosulfonyl)phenyl]pyrid-2-yl]aminocarbonyl]-5-(methylsulfonylaminomethyl)isoxazoline
CAS No.:218301-61-2
Molecular Formula:C₂₈H₂₉FN₆O₆S₂
Molecular Weight:628.705
Hs Code.:

Synonyms:3-(3-cyano-4-fluorophenyl)-5-[[5-[(2'-t-butylaminosulfonyl)phenyl]pyrid-2-yl]aminocarbonyl]-5-(methylsulfonylaminomethyl)isoxazoline

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Chemical Property of 3-(3-cyano-4-fluorophenyl)-5-[[5-[(2'-t-butylaminosulfonyl)phenyl]pyrid-2-yl]aminocarbonyl]-5-(methylsulfonylaminomethyl)isoxazoline

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Technology Process of 3-(3-cyano-4-fluorophenyl)-5-[[5-[(2'-t-butylaminosulfonyl)phenyl]pyrid-2-yl]aminocarbonyl]-5-(methylsulfonylaminomethyl)isoxazoline

There total 7 articles about 3-(3-cyano-4-fluorophenyl)-5-[[5-[(2'-t-butylaminosulfonyl)phenyl]pyrid-2-yl]aminocarbonyl]-5-(methylsulfonylaminomethyl)isoxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 203512-83-8
2-Amino-5-(2-t-butylaminosulfonyl-phenyl)-pyridine

: 3-(3-cyano-4-fluoro-phenyl)-5-(methanesulfonylamino-methyl)-4,5-dihydro-isoxazole-5-carbonyl chloride

: 218301-61-2
3-(3-cyano-4-fluorophenyl)-5-[[5-[(2'-t-butylaminosulfonyl)phenyl]pyrid-2-yl]aminocarbonyl]-5-(methylsulfonylaminomethyl)isoxazoline

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/S0960-894X(03)00080-5

Reference yield:

: 218301-22-5
2-fluoro-5-formylbenzonitrile

: 218301-61-2
3-(3-cyano-4-fluorophenyl)-5-[[5-[(2'-t-butylaminosulfonyl)phenyl]pyrid-2-yl]aminocarbonyl]-5-(methylsulfonylaminomethyl)isoxazoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: 88 percent / NH₂OH / ethanol; pyridine

2.1: 73 percent / bleach / CH₂Cl₂

3.1: P(OEt)3 / tetrahydrofuran

3.2: H⁽¹⁺⁾

4.1: 83 percent / LiOH / tetrahydrofuran

5.1: (COCl)2

6.1: Et₃N / CH₂Cl₂

With lithium hydroxide; sodium hypochlorite; oxalyl dichloride; hydroxylamine; triethylamine; triethyl phosphite; In tetrahydrofuran; pyridine; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(03)00080-5

Reference yield:

: 218301-30-5
2-fluoro-5-[(hydroxyimino)methyl]benzonitrile

: 218301-61-2
3-(3-cyano-4-fluorophenyl)-5-[[5-[(2'-t-butylaminosulfonyl)phenyl]pyrid-2-yl]aminocarbonyl]-5-(methylsulfonylaminomethyl)isoxazoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: 73 percent / bleach / CH₂Cl₂

2.1: P(OEt)3 / tetrahydrofuran

2.2: H⁽¹⁺⁾

3.1: 83 percent / LiOH / tetrahydrofuran

4.1: (COCl)2

5.1: Et₃N / CH₂Cl₂

With lithium hydroxide; sodium hypochlorite; oxalyl dichloride; triethylamine; triethyl phosphite; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(03)00080-5