benzyl N-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-N'-(benzyloxycarbonyl)-α,α-diaminoacetate

Base Information

Chemical Name:benzyl N-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-N'-(benzyloxycarbonyl)-α,α-diaminoacetate
CAS No.:64789-45-3
Molecular Formula:C₂₈H₂₈N₂O₇
Molecular Weight:504.54
Hs Code.:

Synonyms:benzyl N-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-N'-(benzyloxycarbonyl)-α,α-diaminoacetate

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Chemical Property of benzyl N-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-N'-(benzyloxycarbonyl)-α,α-diaminoacetate

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Technology Process of benzyl N-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-N'-(benzyloxycarbonyl)-α,α-diaminoacetate

There total 11 articles about benzyl N-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-N'-(benzyloxycarbonyl)-α,α-diaminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54561-75-0
2-benzyl-3-methoxy-3-oxopropanoic acid

: 64789-44-2
Amino-benzyloxycarbonylamino-acetic acid benzyl ester

: 64789-45-3
benzyl N-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-N'-(benzyloxycarbonyl)-α,α-diaminoacetate

Guidance literature:: With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 12h; Yield given;
DOI:10.1021/jm00178a012

Reference yield:

: 15014-25-2
malonic acid dibenzyl ester

: 64789-45-3
benzyl N-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-N'-(benzyloxycarbonyl)-α,α-diaminoacetate

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) 40percentaq. AcOH, NaNO₃, 2.) Al(Hg), H₂O / 1.) 1,4-dioxane, 2.5 h, 2.) THF, reflux, 1 h

2: sat. aq. NaHCO₃ / 12 h / Ambient temperature

3: 58 percent / LiOH*H₂O / acetone; H₂O / 12 h / Ambient temperature

4: 91 percent / DCC / ethyl acetate / 12 h / Ambient temperature

5: 93 percent / aq. HCl / dioxane / 0.5 h / Ambient temperature

6: NOCl / tetrahydrofuran / 0 °C

7: toluene / 0.5 h / 80 °C

8: toluene / 1 h / 80 °C

9: aq. HCl / dioxane / 0.5 h

10: Et₃N, DCC / CH₂Cl₂ / 12 h / 0 - 20 °C

With hydrogenchloride; lithium hydroxide; sodium nitrate; aluminum amalgam; water; sodium hydrogencarbonate; acetic acid; nitrosylchloride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; acetone; toluene;
DOI:10.1021/jm00178a012

Reference yield:

: 31661-15-1
dibenzyl aminomalonate

: 64789-45-3
benzyl N-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-N'-(benzyloxycarbonyl)-α,α-diaminoacetate

Guidance literature:: Multi-step reaction with 9 steps

1: sat. aq. NaHCO₃ / 12 h / Ambient temperature

2: 58 percent / LiOH*H₂O / acetone; H₂O / 12 h / Ambient temperature

3: 91 percent / DCC / ethyl acetate / 12 h / Ambient temperature

4: 93 percent / aq. HCl / dioxane / 0.5 h / Ambient temperature

5: NOCl / tetrahydrofuran / 0 °C

6: toluene / 0.5 h / 80 °C

7: toluene / 1 h / 80 °C

8: aq. HCl / dioxane / 0.5 h

9: Et₃N, DCC / CH₂Cl₂ / 12 h / 0 - 20 °C

With hydrogenchloride; lithium hydroxide; sodium hydrogencarbonate; nitrosylchloride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; acetone; toluene;
DOI:10.1021/jm00178a012