2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1H-pyrazol-4-yl)-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

Base Information

Chemical Name:2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1H-pyrazol-4-yl)-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide
CAS No.:1362817-99-9
Molecular Formula:C₂₇H₂₇FN₆O₃
Molecular Weight:502.548
Hs Code.:

Synonyms:2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1H-pyrazol-4-yl)-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

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Chemical Property of 2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1H-pyrazol-4-yl)-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

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Technology Process of 2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1H-pyrazol-4-yl)-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

There total 12 articles about 2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1H-pyrazol-4-yl)-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20744-39-2
4-aminopyridazine

: C₂₃H₂₄FN₃O₄

: 1362817-99-9
2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1H-pyrazol-4-yl)-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 3h;

Reference yield:

: 60710-39-6
3-bromo-p-cresol

: 1362817-99-9
2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1H-pyrazol-4-yl)-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: 1 h / 60 °C

1.2: 0.67 h / 180 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: sodium hydroxide; bromine; water / 1,4-dioxane / 1.17 h / 0 - 20 °C

3.2: pH 2

4.1: trifluoroacetic acid; methyl-phenyl-thioether / toluene / 18 h

5.1: thionyl chloride / 72 h / 50 °C

6.1: pyridine / 1 h

7.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C

8.1: triethylamine / acetone / 1 h

9.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 1 h / 120 °C

10.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 40 °C

11.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 50 °C

12.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h

With pyridine; potassium phosphate; N-Bromosuccinimide; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; methyl-phenyl-thioether; water; bromine; potassium carbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1-(4-bromo-2-hydroxy-5-methylphenyl)ethan-1-one

: 1362817-99-9
2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1H-pyrazol-4-yl)-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydroxide; bromine; water / 1,4-dioxane / 1.17 h / 0 - 20 °C

2.2: pH 2

3.1: trifluoroacetic acid; methyl-phenyl-thioether / toluene / 18 h

4.1: thionyl chloride / 72 h / 50 °C

5.1: pyridine / 1 h

6.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C

7.1: triethylamine / acetone / 1 h

8.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 1 h / 120 °C

9.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 40 °C

10.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 50 °C

11.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h

With pyridine; potassium phosphate; N-Bromosuccinimide; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; methyl-phenyl-thioether; water; bromine; potassium carbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; N,N-dimethyl-formamide; acetone; toluene;