20744-39-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Aminopyridazine is used as a building block for the preparation of phosphodiesterase 10A inhibitors, which are important in the development of treatments for neurological and psychiatric disorders. The compound is valued for its ability to reduce CYP1A2 inhibition, a factor that can lead to drug-drug interactions and side effects.
Additionally, 4-Aminopyridazine is utilized in the synthesis of ATP competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) inhibitors. These inhibitors play a crucial role in the development of targeted cancer therapies, as they help regulate cell growth and proliferation pathways.

InChI:InChI=1/C4H5N3/c5-4-1-2-6-7-3-4/h1-3H,(H2,5,6)

Upstream product

• 823-58-5 3,6-dichloropyridazin-4-amine 
• 89180-50-7 5-amino-3,4-dichloropyridazine 
• 289-80-5 1,2-diazine 
• 17114-78-2 9-tert-butylfluorene 
• 14161-11-6 3,4,5-trichloropyridazine 
• 53180-76-0 (3,5-dichloropyridazin-4-yl)amine 

Downstream Products

• 17114-78-2 9-tert-butylfluorene 
• 169050-21-9 tert-butyl N-(4-pyridazinyl)carbamate 
• 115136-48-6 phenyl N-(pyridazin-4-yl)carbamate 
• 945104-55-2 3-(4-tert-butylphenyl)-5,5-dimethyl-1-{[2-(pyridazin-4-ylamino)pyridin-4-yl]methyl}imidazolidine-2,4-dione 
• 1196093-27-2 2-Chloro-N-pyridazin-4-yl-acetamide 
• 1208318-49-3 C₂₈H₂₈N₄O₄ 

Relevant academic research and scientific papers

Synthesis method of 5-chloro-4-aminopyridazine

The invention relates to the technical field of chemical synthesis, and concretely discloses a synthesis method of 5-chloro-4-aminopyridazine. The synthesis method comprises the following steps: 3,6-dichloro-4-aminopyridazine used as an initial raw material undergoes hydrodechlorination to obtain a 4-aminopyridazine key intermediate at a high yield, and then the key intermediate is chlorinated with N-chlorosuccinimide (NCS) to obtain the target product 5-chloro-4-aminopyridazine. The 5-chloro-4-aminopyridazine is a key intermediate for drug synthesis, but the synthesis route of 5-chloro-4-aminopyridazine, especially the synthesis route suitable for commercial mass production, is not reported. The synthesis method of the target compound is provided for the first time, is particularly suitable for commercial mass production, and allows the 5-chloro-4-aminopyridazine to be prepared with high yield and high purity.

NOVEL COMPOUNDS

The present invention discloses novel compounds inhibiting LRRK2 kinase activity, the preparation processes thereof, the compositions containing them, as well as the use in treating diseases characterized by LRRK2 kinase activity, particularly Parkinson's disease and Alzheimer's disease.

AMIDE COMPOUND

There is provided a FAAH inhibitor and a prophylactic or therapeutic agent for cerebrovascular disorders or sleep disorders comprising it. The prophylactic or therapeutic agent comprises a compound of the formula (I0): wherein Z is oxygen or sulfur; R1 is aryl which may be substituted, or a heterocyclic group which may be substituted; R1a is a hydrogen atom, a hydrocarbon group which may be substituted, hydroxyl, etc.; R2 is piperidin-1,4-diyl which may be substituted, or piperazin-1,4-diyl which may be substituted; R3 is a group formed by eliminating two hydrogen atoms from a 5-membered aromatic heterocyclic group having 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur, which may be further substituted, -CO-, etc.; and R4 is a hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; or a salt thereof.

1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO

Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Pyridazinylurea plant regulators

Pyridazinylurea plant regulators of the formula STR1 and acid addition salts thereof; wherein R is alkyl or cycloalkyl, R1 is hydrogen or alkyl, each X independently is halogen, alkoxy, alkylthi or alkylsulfonyl, and p is 0, 1 or 2.

Pyridazinylurea N-oxide plant regulators

Pyridazinylurea N-oxide plant regulators of the formula STR1 and acid addition salts thereof; wherein R is alkyl, cycloalkyl or phenyl optionally substituted with halogen; R1 is hydrogen or alkyl; each X independently is halogen, alkoxy, alkylthio or alkylsulfonyl; p is 0, 1 or 2; and wherein the NHCONRR1 group is bonded to the pyridazinyl ring in the 3- or 4-position; provided that (a) when X is halogen, p is 1 or 2 and the NHCONRR1 group is in the 4-position, the halogen is in at least one of the 5- and 6-positions, and (b) when X is halogen, p is 1 or 2 and the NHCONRR1 group is in the 3-position, the halogen is in at least one of the 4- and 5-positions.

ACIDIFYING EFFECTS OF AZA GROUPS IN THE NH ACIDITY OF AMINOAZINES AND THE CH ACIDITY OF ACETYLAZINES

The pK values for a series of aminoazines and acetylazines containing one, two, or three aza groups in the ring were determined in dimethyl sulfoxide.There is a good linear correlation between pK values of the investigated NH and CH acids.The acidifying effects (ΔpK) of the aza groups at positions 2, 3, or 4 in relation to the side chain were determined and had values of 3.1, 2.4, and 4.5 logarithmic units in the aminoazines and 3.5, 2.9 and 4.8 logarithmic units respectively in the acetylazines.Except in the case of two ortho-located aza groups the effects are additive.Compared with dimethyl sulfoxide water has a differentiating effect on the acidity of the aminoazines, and this is explained by the formation of hydrogen bonds between the molecules of the proton-donating solvent and the aza groups of the anions of the aminoazines.

On the Amination of Azaheterocycles. A New Procedure for the Introduction of an Amino Group

A new method of amination of diazines and triazines, using potassium amide, liquid ammonia and potassium permanganate, has been described.

1-Benzoyl-3-(6-oxopyridazinyl)ureas, compositions, and insecticidal method

Insecticidal agents characterized as 1-(benzoyl)-3-(6-oxopyridazinyl)urea are provided. Agricultural compositions and an insecticidal method are disclosed.