20744-39-2

Basic information

• Product Name: 4-AMINOPYRIDAZINE
• Synonyms: 4-AMINOPYRIDAZINE;PYRIDAZIN-4-AMINE;PYRIDAZIN-4-YLAMINE;4-Pyridazinamine;4-Aminopyridazin;4-aminopyridazine (MFCD00233975);Pyridazin-4-amine, 4-Amino-1,2-diazine
• CAS NO: 20744-39-2
• Molecular Formula: C4H5N3
• Molecular Weight: 95.1
• Product Categories: Amines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 20744-39-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 127-133°C
• Boiling Point: 326.2 °C at 760 mmHg
• Flash Point: 177.3 °C
• Appearance: /
• Density: 1.216 g/cm³
• Vapor Pressure: 0.000219mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: ?20°C
• PKA: 6.38±0.10(Predicted)
• CAS DataBase Reference: 4-AMINOPYRIDAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOPYRIDAZINE(20744-39-2)
• EPA Substance Registry System: 4-AMINOPYRIDAZINE(20744-39-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 20744-39-2(Hazardous Substances Data)

Usage

Uses

4-Pyridazinamine is used to prepare phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition. It is also used to synthesize ATP competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors.

Chemical Properties

yellow powder

InChI:InChI=1/C4H5N3/c5-4-1-2-6-7-3-4/h1-3H,(H2,5,6)

Upstream product

• 823-58-5 3,6-dichloropyridazin-4-amine 
• 89180-50-7 5-amino-3,4-dichloropyridazine 
• 53180-76-0 (3,5-dichloropyridazin-4-yl)amine 
• 289-80-5 1,2-diazine 
• 17114-78-2 9-tert-butylfluorene 
• 14161-11-6 3,4,5-trichloropyridazine 

Downstream Products

• 17114-78-2 9-tert-butylfluorene 
• 169050-21-9 tert-butyl N-(4-pyridazinyl)carbamate 
• 945104-55-2 3-(4-tert-butylphenyl)-5,5-dimethyl-1-{[2-(pyridazin-4-ylamino)pyridin-4-yl]methyl}imidazolidine-2,4-dione 
• 5469-70-5 3-aminopyridazine 
• 1196093-27-2 2-Chloro-N-pyridazin-4-yl-acetamide 
• 53180-92-0 5-chloropyridazin-4-ylamine 

Relevant articles and documents

Synthesis method of 5-chloro-4-aminopyridazine

The invention relates to the technical field of chemical synthesis, and concretely discloses a synthesis method of 5-chloro-4-aminopyridazine. The synthesis method comprises the following steps: 3,6-dichloro-4-aminopyridazine used as an initial raw material undergoes hydrodechlorination to obtain a 4-aminopyridazine key intermediate at a high yield, and then the key intermediate is chlorinated with N-chlorosuccinimide (NCS) to obtain the target product 5-chloro-4-aminopyridazine. The 5-chloro-4-aminopyridazine is a key intermediate for drug synthesis, but the synthesis route of 5-chloro-4-aminopyridazine, especially the synthesis route suitable for commercial mass production, is not reported. The synthesis method of the target compound is provided for the first time, is particularly suitable for commercial mass production, and allows the 5-chloro-4-aminopyridazine to be prepared with high yield and high purity.

AMIDE COMPOUND

There is provided a FAAH inhibitor and a prophylactic or therapeutic agent for cerebrovascular disorders or sleep disorders comprising it. The prophylactic or therapeutic agent comprises a compound of the formula (I0): wherein Z is oxygen or sulfur; R1 is aryl which may be substituted, or a heterocyclic group which may be substituted; R1a is a hydrogen atom, a hydrocarbon group which may be substituted, hydroxyl, etc.; R2 is piperidin-1,4-diyl which may be substituted, or piperazin-1,4-diyl which may be substituted; R3 is a group formed by eliminating two hydrogen atoms from a 5-membered aromatic heterocyclic group having 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur, which may be further substituted, -CO-, etc.; and R4 is a hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; or a salt thereof.

Pyridazinylurea plant regulators

Pyridazinylurea plant regulators of the formula STR1 and acid addition salts thereof; wherein R is alkyl or cycloalkyl, R1 is hydrogen or alkyl, each X independently is halogen, alkoxy, alkylthi or alkylsulfonyl, and p is 0, 1 or 2.