1,4-dimethyl-3-(2'-thiopyridyl)-6-(2''-δ-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer)

Base Information

Chemical Name:1,4-dimethyl-3-(2'-thiopyridyl)-6-(2''-δ-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer)
CAS No.:92098-01-6
Molecular Formula:C₂₇H₂₅N₃O₄S
Molecular Weight:487.579
Hs Code.:

Synonyms:1,4-dimethyl-3-(2'-thiopyridyl)-6-(2''-δ-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer)

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Chemical Property of 1,4-dimethyl-3-(2'-thiopyridyl)-6-(2''-δ-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer)

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Technology Process of 1,4-dimethyl-3-(2'-thiopyridyl)-6-(2''-δ-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer)

There total 5 articles about 1,4-dimethyl-3-(2'-thiopyridyl)-6-(2''-δ-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42492-87-5
N,N'-dibenzylpiperazine-2,5-dione

: 92098-01-6
1,4-dimethyl-3-(2'-thiopyridyl)-6-(2''-δ-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer)

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / N-bromosuccinimide / benzoyl peroxide / CCl₄ / 2 h / Heating

2: 1.) NaH / 1.) THF, room temp., 30 min; 2.) THF, 30 min

3: silver triflate / tetrahydrofuran / 2 h / Ambient temperature

With N-Bromosuccinimide; silver trifluoromethanesulfonate; sodium hydride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane;
DOI:10.1021/ja00297a034

Reference yield:

: 100-39-0
benzyl bromide

: 92098-01-6
1,4-dimethyl-3-(2'-thiopyridyl)-6-(2''-δ-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer)

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide / 25 °C

2: 98 percent / N-bromosuccinimide / benzoyl peroxide / CCl₄ / 2 h / Heating

3: 1.) NaH / 1.) THF, room temp., 30 min; 2.) THF, 30 min

4: silver triflate / tetrahydrofuran / 2 h / Ambient temperature

With N-Bromosuccinimide; silver trifluoromethanesulfonate; sodium hydride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00297a034

Reference yield:

: 89291-86-1
1,4-dibenzyl-3,6-dibromopiperazine-2,5-dione

: 92098-01-6
1,4-dimethyl-3-(2'-thiopyridyl)-6-(2''-δ-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer)

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, room temp., 30 min; 2.) THF, 30 min

2: silver triflate / tetrahydrofuran / 2 h / Ambient temperature

With silver trifluoromethanesulfonate; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ja00297a034