1,4-dibenzyl-3,6-bis(2'-mercaptopyridyl)-2,5-piperazinedione

Base Information

• Chemical Name: 1,4-dibenzyl-3,6-bis(2'-mercaptopyridyl)-2,5-piperazinedione
• CAS No.: 95676-11-2
• Molecular Formula: C₂₈H₂₄N₄O₂S₂
• Molecular Weight: 512.656
• Mol file: 95676-11-2.mol

Synonyms:1,4-dibenzyl-3,6-bis(2'-mercaptopyridyl)-2,5-piperazinedione

Chemical Property of 1,4-dibenzyl-3,6-bis(2'-mercaptopyridyl)-2,5-piperazinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-dibenzyl-3,6-bis(2'-mercaptopyridyl)-2,5-piperazinedione

There total 4 articles about 1,4-dibenzyl-3,6-bis(2'-mercaptopyridyl)-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N'-dibenzylpiperazine-2,5-dione (42492-87-5) → 1,4-dibenzyl-3,6-bis(2'-mercaptopyridyl)-2,5-piperazinedione (95676-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / N-bromosuccinimide / benzoyl peroxide / CCl₄ / 2 h / Heating

2: 1.) NaH / 1.) THF, room temp., 30 min; 2.) THF, 30 min

With N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In tetrachloromethane;

DOI:10.1021/ja00297a034

Reference yield:

benzyl bromide (100-39-0) → 1,4-dibenzyl-3,6-bis(2'-mercaptopyridyl)-2,5-piperazinedione (95676-11-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 25 °C

2: 98 percent / N-bromosuccinimide / benzoyl peroxide / CCl₄ / 2 h / Heating

3: 1.) NaH / 1.) THF, room temp., 30 min; 2.) THF, 30 min

With N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja00297a034

Reference yield:

1,4-dibenzyl-3,6-dibromopiperazine-2,5-dione (89291-86-1) + 2-mercaptopyridine sodium salt (13327-62-3) → 1,4-dibenzyl-3,6-bis(2'-mercaptopyridyl)-2,5-piperazinedione (95676-11-2)

Guidance literature:

In tetrahydrofuran; at 25 ℃; for 0.5h; Yield given;

DOI:10.1021/ja00331a066

upstream raw materials:

2-Sulfanylpyridine

1,4-dibenzyl-3,6-dibromopiperazine-2,5-dione

2-mercaptopyridine sodium salt

N,N'-dibenzylpiperazine-2,5-dione

Downstream raw materials:

1,4-dibenzyl-3-(2'-thiopyridyl)-6-(2-valerolactonyl)-2,5-piperazinedione (syn, minor diastereomer)

1,4-dibenzyl-3-(2'-thiopyridyl)-6-(2-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer)

1,4-dibenzyl-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (anti)

1,4-dibenzyl-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn)