4-({[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamoyl)butanoic acid

Base Information

Chemical Name:4-({[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamoyl)butanoic acid
CAS No.:1620474-92-1
Molecular Formula:C₁₅H₁₇N₅O₃
Molecular Weight:315.332
Hs Code.:

Synonyms:4-({[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamoyl)butanoic acid

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Chemical Property of 4-({[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamoyl)butanoic acid

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Technology Process of 4-({[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamoyl)butanoic acid

There total 5 articles about 4-({[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamoyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108-55-4
glutaric anhydride,

: 1345955-28-3
(4-(6-methyl-1,2,4,5-tetrazin-3- yl)phenyl)methaneamine

: 1620474-92-1
4-({[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamoyl)butanoic acid

Guidance literature:: glutaric anhydride,; (4-(6-methyl-1,2,4,5-tetrazin-3- yl)phenyl)methaneamine; In tetrahydrofuran; at 70 ℃; for 4h; Inert atmosphere;

In tetrahydrofuran; at 50 ℃; for 16h; Inert atmosphere;
DOI:10.1039/c4cc03903c

Reference yield: 53.0%

: C₂₈H₃₇N₁₁O₃

: 1620474-92-1
4-({[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamoyl)butanoic acid

Guidance literature:: C₂₈H₃₇N₁₁O₃; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

With tert-butyl 6-bromohexylcarbamate; In N,N-dimethyl-formamide; for 1h;
DOI:10.1021/acs.molpharmaceut.7b00356

Reference yield:

: 1380500-86-6
tert-butyl N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamate

: 1620474-92-1
4-({[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamoyl)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

2.1: tetrahydrofuran / 4 h / 70 °C / Inert atmosphere

2.2: 16 h / 50 °C / Inert atmosphere

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c4cc03903c