2,2',2''-(10-(1-carboxy-4-((2-(5-((4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)ethyl)amino)-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

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Chemical Name:2,2',2''-(10-(1-carboxy-4-((2-(5-((4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)ethyl)amino)-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid
CAS No.:1620474-93-2
Molecular Formula:C₃₆H₅₃N₁₁O₁₁
Molecular Weight:815.884
Hs Code.:

2,2',2''-(10-(1-carboxy-4-((2-(5-((4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)ethyl)amino)-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Synonyms:2,2',2''-(10-(1-carboxy-4-((2-(5-((4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)ethyl)amino)-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

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Chemical Property of 2,2',2''-(10-(1-carboxy-4-((2-(5-((4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)ethyl)amino)-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

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Technology Process of 2,2',2''-(10-(1-carboxy-4-((2-(5-((4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)ethyl)amino)-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

There total 8 articles about 2,2',2''-(10-(1-carboxy-4-((2-(5-((4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)ethyl)amino)-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1639843-65-4
2,2’,2”-(10-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

: 1620474-92-1
4-({[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamoyl)butanoic acid

: 1620474-93-2
2,2',2''-(10-(1-carboxy-4-((2-(5-((4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)ethyl)amino)-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Guidance literature:: 4-({[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamoyl)butanoic acid; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 25 ℃; for 16h; Darkness;

2,2’,2”-(10-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid; In dimethyl sulfoxide; at 20 ℃; for 5h; Darkness;
DOI:10.1039/c9sc00684b

Reference yield:

: 1454558-58-7
5-[(2,5-dioxopyrrolidin-1-yl)oxy]-N-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl]-5-oxopentanamide

: 1639843-65-4
2,2’,2”-(10-(4-((2-aminoethyl)amino)-1-carboxy-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

: 1620474-93-2
2,2',2''-(10-(1-carboxy-4-((2-(5-((4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)ethyl)amino)-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c4cc03903c

Reference yield:

: 1380500-86-6
tert-butyl N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamate

: 1620474-93-2
2,2',2''-(10-(1-carboxy-4-((2-(5-((4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)ethyl)amino)-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

2.1: tetrahydrofuran / 4 h / 70 °C / Inert atmosphere

2.2: 16 h / 50 °C / Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere

4.1: triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c4cc03903c