tert-butyl N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamate

Base Information

• Chemical Name: tert-butyl N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamate
• CAS No.: 1380500-86-6
• Molecular Formula: C₁₅H₁₉N₅O₂
• Molecular Weight: 301.348
• Mol file: 1380500-86-6.mol

Synonyms:tert-butyl N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamate

Chemical Property of tert-butyl N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

tert-ButylN-(((4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl)methyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamate

There total 8 articles about tert-butyl N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-((tert-butoxycarbonylamino)methyl)phenylboronic acid (489446-42-6) + 3-([1,1'-biphenyl]-4-ylmethylthio)-6-methyl-1,2,4,5-tetrazine → tert-butyl N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamate (1380500-86-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; silver(l) oxide; In N,N-dimethyl-formamide; at 60 ℃; Inert atmosphere; Sealed tube; Schlenk technique;

DOI:10.1021/jacs.9b08677

Reference yield: 70.0%

tert-butyl N-[(4-cyanophenyl)methyl]carbamate (66389-80-8) → tert-butyl N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamate (1380500-86-6)

Guidance literature:

tert-butyl N-[(4-cyanophenyl)methyl]carbamate; With nickel(II) chloride hexahydrate; hydrazine hydrate; In acetonitrile; at 60 ℃; Sealed tube;

With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.25h; pH=3;

DOI:10.1021/acs.joc.0c00583

Reference yield: 68.0%

tert-butyl N-[(4-cyanophenyl)methyl]carbamate (66389-80-8) + acetonitrile (75-05-8,26809-02-9) → tert-butyl N-{[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamate (1380500-86-6)

Guidance literature:

tert-butyl N-[(4-cyanophenyl)methyl]carbamate; acetonitrile; With nickel(II) triflate; hydrazine; at 60 ℃; for 24h; Microwave irradiation;

With hydrogenchloride; sodium nitrite; In water; at 20 ℃; pH=3;

DOI:10.1002/anie.201201117

upstream raw materials:

tert-butyl N-[(4-cyanophenyl)methyl]carbamate

acetonitrile

di-tert-butyl dicarbonate

4-cyanobenzylamine hydrochloride

Downstream raw materials:

5-[(2,5-dioxopyrrolidin-1-yl)oxy]-N-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl]-5-oxopentanamide

(4-(6-methyl-1,2,4,5-tetrazin-3- yl)phenyl)methaneamine

4-({[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl}carbamoyl)butanoic acid

2,2',2''-(10-(1-carboxy-4-((2-(5-((4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanamido)ethyl)amino)-4-oxobutyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid