5'-O-(4,4'-dimethoxytrityl)-2'-(2-ethoxy-3,4-dioxocyclobuten-1-yl)-amino-2',3'-dideoxyuridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-(2-ethoxy-3,4-dioxocyclobuten-1-yl)-amino-2',3'-dideoxyuridine
CAS No.:726201-59-8
Molecular Formula:C₃₆H₃₅N₃O₉
Molecular Weight:653.689
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-(2-ethoxy-3,4-dioxocyclobuten-1-yl)-amino-2',3'-dideoxyuridine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-(2-ethoxy-3,4-dioxocyclobuten-1-yl)-amino-2',3'-dideoxyuridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-(2-ethoxy-3,4-dioxocyclobuten-1-yl)-amino-2',3'-dideoxyuridine

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-(2-ethoxy-3,4-dioxocyclobuten-1-yl)-amino-2',3'-dideoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 5231-87-8
3,4-diethoxy-3-cyclobuten-1,2-dione

: 2'-amino-5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxyuridine

: 726201-59-8
5'-O-(4,4'-dimethoxytrityl)-2'-(2-ethoxy-3,4-dioxocyclobuten-1-yl)-amino-2',3'-dideoxyuridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 20 ℃; for 2.5h;
DOI:10.1002/ejoc.200300682

Reference yield: 100.0%

: 25152-20-9
5'-amino-5'-deoxythymidine

: 726201-59-8
5'-O-(4,4'-dimethoxytrityl)-2'-(2-ethoxy-3,4-dioxocyclobuten-1-yl)-amino-2',3'-dideoxyuridine

: 726201-60-1
N'-[3'deoxy-5'-O-(4,4'-dimethoxytrityl)uridin-2'-yl]-3,4-dioxo-N-(thymidin-5'-yl)cyclobutene-1,2-diamine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; at 40 ℃; for 20h;
DOI:10.1002/ejoc.200300682

Reference yield:

: 726201-59-8
5'-O-(4,4'-dimethoxytrityl)-2'-(2-ethoxy-3,4-dioxocyclobuten-1-yl)-amino-2',3'-dideoxyuridine

: C₅₃H₆₁N₈O₁₃P

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / diisopropylethylamine / CH₂Cl₂; ethanol / 20 h / 40 °C

2: 75 percent / triethylamine / tetrahydrofuran / 3.5 h / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/ejoc.200300682