N'-[3'deoxy-5'-O-(4,4'-dimethoxytrityl)uridin-2'-yl]-3,4-dioxo-N-(thymidin-5'-yl)cyclobutene-1,2-diamine

Base Information

• Chemical Name: N'-[3'deoxy-5'-O-(4,4'-dimethoxytrityl)uridin-2'-yl]-3,4-dioxo-N-(thymidin-5'-yl)cyclobutene-1,2-diamine
• CAS No.: 726201-60-1
• Molecular Formula: C₄₄H₄₄N₆O₁₂
• Molecular Weight: 848.866

Synonyms:N'-[3'deoxy-5'-O-(4,4'-dimethoxytrityl)uridin-2'-yl]-3,4-dioxo-N-(thymidin-5'-yl)cyclobutene-1,2-diamine

Chemical Property of N'-[3'deoxy-5'-O-(4,4'-dimethoxytrityl)uridin-2'-yl]-3,4-dioxo-N-(thymidin-5'-yl)cyclobutene-1,2-diamine

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Technology Process of N'-[3'deoxy-5'-O-(4,4'-dimethoxytrityl)uridin-2'-yl]-3,4-dioxo-N-(thymidin-5'-yl)cyclobutene-1,2-diamine

There total 2 articles about N'-[3'deoxy-5'-O-(4,4'-dimethoxytrityl)uridin-2'-yl]-3,4-dioxo-N-(thymidin-5'-yl)cyclobutene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5'-amino-5'-deoxythymidine (25152-20-9) + 5'-O-(4,4'-dimethoxytrityl)-2'-(2-ethoxy-3,4-dioxocyclobuten-1-yl)-amino-2',3'-dideoxyuridine (726201-59-8) → N'-[3'deoxy-5'-O-(4,4'-dimethoxytrityl)uridin-2'-yl]-3,4-dioxo-N-(thymidin-5'-yl)cyclobutene-1,2-diamine (726201-60-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; at 40 ℃; for 20h;

DOI:10.1002/ejoc.200300682

Reference yield:

2'-amino-5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxyuridine → N'-[3'deoxy-5'-O-(4,4'-dimethoxytrityl)uridin-2'-yl]-3,4-dioxo-N-(thymidin-5'-yl)cyclobutene-1,2-diamine (726201-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / diisopropylethylamine / ethanol / 2.5 h / 20 °C

2: 100 percent / diisopropylethylamine / CH₂Cl₂; ethanol / 20 h / 40 °C

With N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

DOI:10.1002/ejoc.200300682

Reference yield: 75.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + N'-[3'deoxy-5'-O-(4,4'-dimethoxytrityl)uridin-2'-yl]-3,4-dioxo-N-(thymidin-5'-yl)cyclobutene-1,2-diamine (726201-60-1) → C53H61N8O13P

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 3.5h;

DOI:10.1002/ejoc.200300682

upstream raw materials:

5'-amino-5'-deoxythymidine

5'-O-(4,4'-dimethoxytrityl)-2'-(2-ethoxy-3,4-dioxocyclobuten-1-yl)-amino-2',3'-dideoxyuridine

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