methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]-3-hydroxypropanoate

Base Information

Chemical Name:methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]-3-hydroxypropanoate
CAS No.:1259023-65-8
Molecular Formula:C₂₃H₂₁ClFN₃O₄
Molecular Weight:457.889
Hs Code.:

Synonyms:methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]-3-hydroxypropanoate

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Chemical Property of methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]-3-hydroxypropanoate

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Technology Process of methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]-3-hydroxypropanoate

There total 5 articles about methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1259023-63-6
methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]acetate

: 1259023-65-8
methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]-3-hydroxypropanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1039/c2md20190a

Reference yield:

: 1259022-73-5
6-(3-fluoro-4-hydroxyphenyl)-3,5-dimethylpyrazine-2-carboxamide

: 1259023-65-8
methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrahydrofuran / 120 °C

2: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium chloride / 1,2-dimethoxyethane; water; methanol / 65 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; lithium chloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2md20190a

Reference yield:

: 1259022-72-4
[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl] trifluoromethanesulfonate

: 1259023-65-8
methyl 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-fluorophenyl]-3-chlorophenyl]-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium chloride / 1,2-dimethoxyethane; water; methanol / 65 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; lithium chloride; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c2md20190a