2-(2-METHYLPHENYL)ACETOPHENONE

Base Information

• Chemical Name: 2-(2-METHYLPHENYL)ACETOPHENONE
• CAS No.: 5033-67-0
• Molecular Formula: C15H14O
• Molecular Weight: 210.276
• Hs Code.: 2914399090
• Mol file: 5033-67-0.mol

Synonyms:2-(2-METHYLPHENYL)ACETOPHENONE;1-phenyl-2-(o-tolyl)ethanone;2'-methyl-deoxybenzoin;2-(2-methylphenyl)-1-phenyl-ethanone;2-(1-METHYL-3-PYRROLIDINYL)ACETIC ACID;2-(2-methylphenyl)-1-phenyl-1-ethanone;

Chemical Property of 2-(2-METHYLPHENYL)ACETOPHENONE

Chemical Property:

• Vapor Pressure: 8.77E-05mmHg at 25°C
• Boiling Point: 340.1°C at 760 mmHg
• Flash Point: 146.2°C
• PSA: 17.07000
• Density: 1.062g/cm³
• LogP: 3.42040

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Methylphenyl)acetophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-METHYLPHENYL)ACETOPHENONE

There total 49 articles about 2-(2-METHYLPHENYL)ACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-phenylethynyltoluene (14309-60-5) → 2-(2-methylphenyl)-1-phenyl-1-ethanone (5033-67-0)

Guidance literature:

With water; PtCl₄-CO; In tetrahydrofuran; at 80 ℃; for 3h; under 1034.3 Torr;

DOI:10.1021/jo961740m

Reference yield: 99.0%

2-methylchlorobenzene (95-49-8) + acetophenone (98-86-2) → 2-(2-methylphenyl)-1-phenyl-1-ethanone (5033-67-0)

Guidance literature:

With C₄₁H₅₀ClN₃Pd; sodium t-butanolate; In 1,4-dioxane; at 100 ℃; for 4h;

DOI:10.1016/j.tetlet.2020.152124

Reference yield: 99.0%

2-methylchlorobenzene (95-49-8) + 1-Phenylethanol (98-85-1,13323-81-4) → 2-(2-methylphenyl)-1-phenyl-1-ethanone (5033-67-0)

Guidance literature:

1-Phenylethanol; With allylchloro[1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidine]palladium(II); para-chlorotoluene; potassium tert-butylate; In toluene; at 40 ℃; for 3h; Inert atmosphere;

2-methylchlorobenzene; In toluene; at 80 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jo102385u

upstream raw materials:

diphenyl cadmium

(o-tolyl)acetyl chloride

benzene

1-styrenyloxytrimethylsilane

Downstream raw materials:

2-hydroxy-2-phenylindan

3-phenyl-4-o-tolyl-1,2,5-thiadiazole

α-(o-tolyl)valerophenone

2-(2-methylphenyl)-1-phenylpropan-1-one

Refernces

• 1、 Luo, Mengqiang,Zhang, Yaohong,Fang, Ping,Li, Yan,Qi, Chenze,Li, Yong,Shen, Runpu,Cheng, Kai,Wang, Hai. "H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water". supporting information. p. 630 - 635. Retrieved 2022/02/01.
• 2、 Ageshina, Alexandra A.,Asachenko, Andrey F.,Chesnokov, Gleb A.,Minaeva, Lidiya I.,Nechaev, Mikhail S.,Philippova, Anna N.,Rzhevskiy, Sergey A.,Topchiy, Maxim A.. "Ring size and nothing else matters: unusual regioselectivity of alkyne hydration by NHC gold(i) complexes". supporting information. p. 5686 - 5689. Retrieved 2021/06/16.