13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[2,1-d][1,4]benzodiazepine-10-carboxylic acid

Base Information

Chemical Name:13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[2,1-d][1,4]benzodiazepine-10-carboxylic acid
CAS No.:863567-20-8
Molecular Formula:C₂₃H₂₂N₂O₃
Molecular Weight:374.439
Hs Code.:

Synonyms:13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[2,1-d][1,4]benzodiazepine-10-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[2,1-d][1,4]benzodiazepine-10-carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[2,1-d][1,4]benzodiazepine-10-carboxylic acid

There total 6 articles about 13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[2,1-d][1,4]benzodiazepine-10-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 863566-97-6
13-cyclohexyl-6-oxo-6,7-dihydro-5H-benzo[5,6][1,4]diazepino[7,1-a]indole-10-carboxylic acid methyl ester

: 863567-20-8
13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[2,1-d][1,4]benzodiazepine-10-carboxylic acid

Guidance literature:: 13-cyclohexyl-6-oxo-6,7-dihydro-5H-benzo[5,6][1,4]diazepino[7,1-a]indole-10-carboxylic acid methyl ester; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 100 ℃; for 0.25h; Microwave irradiation;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: C₂₃H₂₄N₂O₄

: 863567-20-8
13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[2,1-d][1,4]benzodiazepine-10-carboxylic acid

Guidance literature:: With acetic acid; at 80 ℃; for 1h;

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 863567-20-8
13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[2,1-d][1,4]benzodiazepine-10-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / ethanol; toluene

3: trifluoroacetic acid / dichloromethane

4: water; sodium hydroxide / tetrahydrofuran; methanol / 0.17 h / 90 °C / Microwave irradiation

5: trifluoroacetic acid / dichloromethane

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium hydride; sodium carbonate; trifluoroacetic acid; lithium chloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.03.067