1-adamantanyl 2,3-di-O-benzoyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-β-D-galactopyranoside

Base Information

Chemical Name:1-adamantanyl 2,3-di-O-benzoyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-β-D-galactopyranoside
CAS No.:887699-87-8
Molecular Formula:C₃₉H₃₈INO₈
Molecular Weight:775.637
Hs Code.:

Synonyms:1-adamantanyl 2,3-di-O-benzoyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-β-D-galactopyranoside

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Chemical Property of 1-adamantanyl 2,3-di-O-benzoyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-β-D-galactopyranoside

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Technology Process of 1-adamantanyl 2,3-di-O-benzoyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-β-D-galactopyranoside

There total 9 articles about 1-adamantanyl 2,3-di-O-benzoyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-β-D-galactopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 887699-86-7
1-S-phenyl 2,3-di-O-benzoyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-β-D-galactopyranoside

: 768-95-6
1-adamanthanol

: 887699-87-8
1-adamantanyl 2,3-di-O-benzoyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-β-D-galactopyranoside

Guidance literature:: 1-S-phenyl 2,3-di-O-benzoyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-β-D-galactopyranoside; With trifluoromethylsulfonic anhydride; 1,1'-sulfinylbisbenzene; 2,4,5-tri-tert-butylpyrimidine; molecular sieve; In dichloromethane; at -70 ℃; for 0.5h;

1-adamanthanol; In dichloromethane; at -70 ℃; for 2h;
DOI:10.1021/jo0526688

Reference yield:

: 887699-73-2
triethyl 2-(2-iodophenyl)orthoacetate

: 887699-87-8
1-adamantanyl 2,3-di-O-benzoyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-β-D-galactopyranoside

Guidance literature:: Multi-step reaction with 5 steps

1.1: CSA / CH₂Cl₂ / 3 h / 20 °C

2.1: 2.02 g / CH₂Cl₂ / 1.5 h / 20 °C

3.1: NaOMe / methanol / 1 h

4.1: 1.23 g / pyridine

5.1: Ph₂SO; tri-tert-butyl-pyrimidine; triflic anhydride / molecular sieves / CH₂Cl₂ / 0.5 h / -70 °C

5.2: 89 percent / CH₂Cl₂ / 2 h / -70 °C

With pyridine; trifluoromethylsulfonic anhydride; 1,1'-sulfinylbisbenzene; 2,4,5-tri-tert-butylpyrimidine; camphor-10-sulfonic acid; sodium methylate; molecular sieve; In methanol; dichloromethane;
DOI:10.1021/jo0526688

Reference yield:

: ethyl (2-iodophenyl)iminoacetate hydrochloride

: 887699-87-8
1-adamantanyl 2,3-di-O-benzoyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-β-D-galactopyranoside

Guidance literature:: Multi-step reaction with 6 steps

1.1: 48 h / 20 °C

2.1: CSA / CH₂Cl₂ / 3 h / 20 °C

3.1: 2.02 g / CH₂Cl₂ / 1.5 h / 20 °C

4.1: NaOMe / methanol / 1 h

5.1: 1.23 g / pyridine

6.1: Ph₂SO; tri-tert-butyl-pyrimidine; triflic anhydride / molecular sieves / CH₂Cl₂ / 0.5 h / -70 °C

6.2: 89 percent / CH₂Cl₂ / 2 h / -70 °C

With pyridine; trifluoromethylsulfonic anhydride; 1,1'-sulfinylbisbenzene; 2,4,5-tri-tert-butylpyrimidine; camphor-10-sulfonic acid; sodium methylate; molecular sieve; In methanol; dichloromethane;
DOI:10.1021/jo0526688