triethyl 2-(2-iodophenyl)orthoacetate

Base Information

• Chemical Name: triethyl 2-(2-iodophenyl)orthoacetate
• CAS No.: 887699-73-2
• Molecular Formula: C₁₄H₂₁IO₃
• Molecular Weight: 364.223
• Mol file: 887699-73-2.mol

Synonyms:triethyl 2-(2-iodophenyl)orthoacetate

Chemical Property of triethyl 2-(2-iodophenyl)orthoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of triethyl 2-(2-iodophenyl)orthoacetate

There total 2 articles about triethyl 2-(2-iodophenyl)orthoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-iodophenyl)acetonitrile (40400-15-5) → triethyl 2-(2-iodophenyl)orthoacetate (887699-73-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / HCl / 0 °C

2: 48 h / 20 °C

With hydrogenchloride; 1: Pinner synthesis;

DOI:10.1021/jo0526688

Reference yield:

ethyl (2-iodophenyl)iminoacetate hydrochloride + ethanol (64-17-5) → triethyl 2-(2-iodophenyl)orthoacetate (887699-73-2) + ethyl 2-(2-iodophenyl)acetate (90794-29-9)

Guidance literature:

at 20 ℃; for 48h; Title compound not separated from byproducts;

DOI:10.1021/jo0526688

Reference yield: 68.0%

triethyl 2-(2-iodophenyl)orthoacetate (887699-73-2) + phenyl 2-O-benzyl-3-O-(naphth-2-ylmethyl)-1-thio-α-D-mannopyranoside + trimethylsilyl cyanide (7677-24-9) → S-phenyl-2-O-benzyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-3-O-(2-naphthalenylmethyl)-1-thio-α-D-mannopyranoside (911811-33-1)

Guidance literature:

triethyl 2-(2-iodophenyl)orthoacetate; phenyl 2-O-benzyl-3-O-(naphth-2-ylmethyl)-1-thio-α-D-mannopyranoside; With camphor-10-sulfonic acid; 4-(2-iodophenyl)butanoic acid; In dichloromethane; at 0 ℃; for 4h;

trimethylsilyl cyanide; With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃;

DOI:10.1021/ol061706m

upstream raw materials:

ethanol

2-(2-iodophenyl)acetonitrile

Downstream raw materials:

phenyl 3-O-allyl-2,7-di-O-benyl-4,6-O-[1-cyano-2-(2-iodophenyl)ethylidene]-L-glycero-α-D-thio-manno-heptopyranoside

phenyl 2,7-di-O-benzyl-4,6-O-[1-cyano-2-(2-iodophenyl)ethylidene]-3-O-(2-naphthalenylmethyl)-L-glycero-α-D-thio-manno-heptopyranoside

S-phenyl-2-O-benzyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-3-O-(2-naphthalenylmethyl)-1-thio-α-D-mannopyranoside

1-cyclohexyl-2-O-benzyl-4,6-O-[1-cyano-2-(2-iodophenyl)]ethylidene-β-D-mannopyranoside