[1-[(S)-7-Benzyloxy-1-(2-chloro-4,5-dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine

Base Information

Chemical Name:[1-[(S)-7-Benzyloxy-1-(2-chloro-4,5-dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine
CAS No.:143371-58-8
Molecular Formula:C₃₆H₄₇ClN₂O₅
Molecular Weight:623.233
Hs Code.:

[1-[(S)-7-Benzyloxy-1-(2-chloro-4,5-dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine

Synonyms:[1-[(S)-7-Benzyloxy-1-(2-chloro-4,5-dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine

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Chemical Property of [1-[(S)-7-Benzyloxy-1-(2-chloro-4,5-dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine

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Technology Process of [1-[(S)-7-Benzyloxy-1-(2-chloro-4,5-dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine

There total 2 articles about [1-[(S)-7-Benzyloxy-1-(2-chloro-4,5-dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133230-10-1
2-chloro-4,5-dimethoxybenzyl bromide

: 123190-98-7
[1-(7-Benzyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine

: 143371-58-8
[1-[(S)-7-Benzyloxy-1-(2-chloro-4,5-dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine

Guidance literature:: With sec.-butyllithium; In tetrahydrofuran; at -78 ℃; for 20h;
DOI:10.1021/jo00039a029

Reference yield:

: 133320-18-0
(S)-valinol-tert-butyl ether formamidine of 7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 133230-10-1
2-chloro-4,5-dimethoxybenzyl bromide

: 143371-58-8
[1-[(S)-7-Benzyloxy-1-(2-chloro-4,5-dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine

Guidance literature:: With sec.-butyllithium; Multistep reaction; 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 15 min;
DOI:10.1021/ja00048a020

Reference yield:

: 143371-58-8
[1-[(S)-7-Benzyloxy-1-(2-chloro-4,5-dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine

: 133320-19-1
dibenzopyrrocoline

Guidance literature:: Multi-step reaction with 2 steps

1: CH₃COOH, hydrazine / ethanol; H₂O / 12 h / Ambient temperature

2: 98 percent / n-BuLi / tetrahydrofuran / 0.25 h / -100 °C

With n-butyllithium; acetic acid; hydrazine; In tetrahydrofuran; ethanol; water;
DOI:10.1021/ja00048a020