2-Chloro-4,5-dimethoxybenzyl bromide

Base Information

• Chemical Name: 2-Chloro-4,5-dimethoxybenzyl bromide
• CAS No.: 133230-10-1
• Molecular Formula: C9H10BrClO2
• Molecular Weight: 265.534
• DSSTox Substance ID: DTXSID00579766
• Wikidata: Q82470380

Synonyms:133230-10-1;1-(Bromomethyl)-2-chloro-4,5-dimethoxybenzene;Benzene, 1-(bromomethyl)-2-chloro-4,5-dimethoxy-;2-chloro-4,5-dimethoxybenzyl bromide;SCHEMBL3390630;DTXSID00579766;AKOS013398291

Chemical Property of 2-Chloro-4,5-dimethoxybenzyl bromide

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 263.95527
• Heavy Atom Count: 13
• Complexity: 157

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C(=C1)CBr)Cl)OC

Technology Process of 2-Chloro-4,5-dimethoxybenzyl bromide

There total 3 articles about 2-Chloro-4,5-dimethoxybenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloroverataldehyde (18093-05-5) → 2-chloro-4,5-dimethoxybenzyl bromide (133230-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / dichloromethane / 0.5 h / 20 °C

2: phosphorus tribromide / dichloromethane / 0.5 h / 0 °C

With sodium tetrahydroborate; phosphorus tribromide; In dichloromethane;

DOI:10.1016/j.ejmech.2012.07.010

Reference yield:

(2-chloro-4,5-dimethoxy-phenyl)-methanol (20624-89-9) → 2-chloro-4,5-dimethoxybenzyl bromide (133230-10-1)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2012.07.010

Reference yield:

→ 2-chloro-4,5-dimethoxybenzyl bromide (133230-10-1)

Guidance literature:

upstream raw materials:

(2-chloro-4,5-dimethoxy-phenyl)-methanol

6-chloroverataldehyde

Downstream raw materials:

[1-[(S)-7-Benzyloxy-1-(2-chloro-4,5-dimethoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((S)-1-tert-butoxymethyl-2-methyl-propyl)-amine

C₂₀H₂₂ClNO₄

1-(2-chloro-4,5-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

2-[2-(2-chloro-4,5-dimethoxyphenyl)ethyl]-6,7-dimethoxy-3,4-dihydroisoquinolinium trifluoroacetate

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