2-(tert-butyldimethylsilyl)-5-((4-methoxy-3,5-dimethylphenyl)sulfinyl)N,N-dimethylimidazole-1-sulfonamide

Base Information

Chemical Name:2-(tert-butyldimethylsilyl)-5-((4-methoxy-3,5-dimethylphenyl)sulfinyl)N,N-dimethylimidazole-1-sulfonamide
CAS No.:1609648-50-1
Molecular Formula:C₂₀H₃₃N₃O₄S₂Si
Molecular Weight:471.717
Hs Code.:

Synonyms:2-(tert-butyldimethylsilyl)-5-((4-methoxy-3,5-dimethylphenyl)sulfinyl)N,N-dimethylimidazole-1-sulfonamide

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Chemical Property of 2-(tert-butyldimethylsilyl)-5-((4-methoxy-3,5-dimethylphenyl)sulfinyl)N,N-dimethylimidazole-1-sulfonamide

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Technology Process of 2-(tert-butyldimethylsilyl)-5-((4-methoxy-3,5-dimethylphenyl)sulfinyl)N,N-dimethylimidazole-1-sulfonamide

There total 3 articles about 2-(tert-butyldimethylsilyl)-5-((4-methoxy-3,5-dimethylphenyl)sulfinyl)N,N-dimethylimidazole-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 4-methoxy-3,5-dimethylbenzene-1-sulfinyl chloride

: 129378-52-5
2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide

: 1609648-50-1
2-(tert-butyldimethylsilyl)-5-((4-methoxy-3,5-dimethylphenyl)sulfinyl)N,N-dimethylimidazole-1-sulfonamide

Guidance literature:: 2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

4-methoxy-3,5-dimethylbenzene-1-sulfinyl chloride; In tetrahydrofuran; at -20 - 20 ℃; for 4h; Inert atmosphere; Schlenk technique;
DOI:10.1002/anie.201309217

Reference yield:

: 78162-58-0
N,N-dimethyl-1H-imidazole-1-sulfonamide

: 1609648-50-1
2-(tert-butyldimethylsilyl)-5-((4-methoxy-3,5-dimethylphenyl)sulfinyl)N,N-dimethylimidazole-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 25 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Schlenk technique

2.2: 4 h / -20 - 20 °C / Inert atmosphere; Schlenk technique

With n-butyllithium; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran;
DOI:10.1002/anie.201309217

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1609648-50-1
2-(tert-butyldimethylsilyl)-5-((4-methoxy-3,5-dimethylphenyl)sulfinyl)N,N-dimethylimidazole-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 25 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Schlenk technique

2.2: 4 h / -20 - 20 °C / Inert atmosphere; Schlenk technique

With n-butyllithium; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran;
DOI:10.1002/anie.201309217