tert-butyl 4-(((5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)(methyl)amino)carbonyl)-1-piperidinecarboxylate

Base Information

Chemical Name:tert-butyl 4-(((5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)(methyl)amino)carbonyl)-1-piperidinecarboxylate
CAS No.:931112-75-3
Molecular Formula:C₃₂H₃₁Cl₂F₃N₄O₅
Molecular Weight:679.523
Hs Code.:

tert-butyl 4-(((5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)(methyl)amino)carbonyl)-1-piperidinecarboxylate

Synonyms:tert-butyl 4-(((5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)(methyl)amino)carbonyl)-1-piperidinecarboxylate

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Chemical Property of tert-butyl 4-(((5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)(methyl)amino)carbonyl)-1-piperidinecarboxylate

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Technology Process of tert-butyl 4-(((5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)(methyl)amino)carbonyl)-1-piperidinecarboxylate

There total 4 articles about tert-butyl 4-(((5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)(methyl)amino)carbonyl)-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 931112-72-0
6-(5-chloro-2-hydroxy-3-((methylamino)methyl)phenyl)-4-(2-chloro-5-(trifluoromethyl)phenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 931112-75-3
tert-butyl 4-(((5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)(methyl)amino)carbonyl)-1-piperidinecarboxylate

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2007.03.042

Reference yield:

: 931112-50-4
6-(5-chloro-2-hydroxyphenyl)-4-(2-chloro-5-(trifluoromethyl)phenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile

: 931112-75-3
tert-butyl 4-(((5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)(methyl)amino)carbonyl)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: NIS / acetonitrile / Heating

2: dppf; Et₃N; Et₃SiH / Pd(OAc)2 / dimethylformamide / 80 °C

3: NaBH(OAc)3 / 1,2-dichloro-ethane

4: polymer-supported-DCC; HOBt*H₂O; DIPEA / N,N-dimethyl-acetamide

With triethylsilane; 1,1'-bis-(diphenylphosphino)ferrocene; N-iodo-succinimide; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; In N,N-dimethyl acetamide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2007.03.042

Reference yield:

: 931112-51-5
6-(5-chloro-2-hydroxy-3-iodophenyl)-4-(2-chloro-5-(trifluoromethyl)phenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile

: 931112-75-3
tert-butyl 4-(((5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)(methyl)amino)carbonyl)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dppf; Et₃N; Et₃SiH / Pd(OAc)2 / dimethylformamide / 80 °C

2: NaBH(OAc)3 / 1,2-dichloro-ethane

3: polymer-supported-DCC; HOBt*H₂O; DIPEA / N,N-dimethyl-acetamide

With triethylsilane; 1,1'-bis-(diphenylphosphino)ferrocene; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; In N,N-dimethyl acetamide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.03.042