3-[2-(4-(2-fluoro-benzyloxy)-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-yl]-propionic acid t-butyl ester

Base Information

Chemical Name:3-[2-(4-(2-fluoro-benzyloxy)-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-yl]-propionic acid t-butyl ester
CAS No.:1354910-22-7
Molecular Formula:C₂₆H₂₉FN₂O₃S
Molecular Weight:468.592
Hs Code.:

Synonyms:3-[2-(4-(2-fluoro-benzyloxy)-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-yl]-propionic acid t-butyl ester

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Chemical Property of 3-[2-(4-(2-fluoro-benzyloxy)-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-yl]-propionic acid t-butyl ester

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Technology Process of 3-[2-(4-(2-fluoro-benzyloxy)-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-yl]-propionic acid t-butyl ester

There total 5 articles about 3-[2-(4-(2-fluoro-benzyloxy)-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-yl]-propionic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 446-51-5
2-fluorobenzyl alcohol

: 1354910-21-6
3-[2-(4-hydroxy-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-yl]-propionic acid t-butyl ester

: 1354910-22-7
3-[2-(4-(2-fluoro-benzyloxy)-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-yl]-propionic acid t-butyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In ISOPROPYLAMIDE; at 20 ℃; for 16h;

Reference yield:

: 174184-13-5
benzyl 3-bromo-4-oxo-piperidine-1-carboxylate

: 1354910-22-7
3-[2-(4-(2-fluoro-benzyloxy)-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-yl]-propionic acid t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 17 h / Reflux

2: boron tribromide; ethanol / 16 h / -78 - 20 °C

3: N-ethyl-N,N-diisopropylamine / methanol / 16 h / Reflux

4: triphenylphosphine; di-isopropyl azodicarboxylate / ISOPROPYLAMIDE / 16 h / 20 °C

With ethanol; di-isopropyl azodicarboxylate; boron tribromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; ethanol; ISOPROPYLAMIDE; 3: Michael Condensation / 4: Mitsunobu reaction;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1354910-22-7
3-[2-(4-(2-fluoro-benzyloxy)-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-yl]-propionic acid t-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.5 h / 0 °C

1.2: 16 h / 20 °C

2.1: ethanol / 17 h / Reflux

3.1: boron tribromide; ethanol / 16 h / -78 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / methanol / 16 h / Reflux

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / ISOPROPYLAMIDE / 16 h / 20 °C

With ethanol; trimethylsilyl trifluoromethanesulfonate; di-isopropyl azodicarboxylate; boron tribromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; 4.1: Michael Condensation / 5.1: Mitsunobu reaction;