1-Piperidinecarboxylic acid, 3-broMo-4-oxo-, phenylMethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 3-broMo-4-oxo-, phenylMethyl ester
• CAS No.: 174184-13-5
• Molecular Formula: C₁₃H₁₄BrNO₃
• Molecular Weight: 312.163
• Hs Code.: 2933399990
• Mol file: 174184-13-5.mol

Synonyms:benzyl 3-bromo-4-oxo-piperidine-1-carboxylate

Chemical Property of 1-Piperidinecarboxylic acid, 3-broMo-4-oxo-, phenylMethyl ester

Chemical Property:

• Boiling Point: 423.7±45.0 °C(Predicted)
• PKA: -3.40±0.40(Predicted)
• Density: 1.510±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-4-oxopiperidine-1-carboxylic acid benzyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-Piperidinecarboxylic acid, 3-broMo-4-oxo-, phenylMethyl ester

There total 1 articles about 1-Piperidinecarboxylic acid, 3-broMo-4-oxo-, phenylMethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → benzyl 3-bromo-4-oxo-piperidine-1-carboxylate (174184-13-5)

Guidance literature:

benzyl 4-oxo-1-piperidinecarboxylate; With trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.5h;

With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 49.0%

benzyl 3-bromo-4-oxo-piperidine-1-carboxylate (174184-13-5) + p-methoxythiobenzamide (2362-64-3) → 2-(4-methoxy-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid benzyl ester (1354910-20-5)

Guidance literature:

In ethanol; for 17h; Reflux;

Reference yield: 28.5%

benzyl 3-bromo-4-oxo-piperidine-1-carboxylate (174184-13-5) + 2-(N-t-butoxycarbonylamino)thioacetamide (89226-13-1) → benzyl 2-(aminomethyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylate

Guidance literature:

In isopropyl alcohol; at 90 ℃; for 16h;

upstream raw materials:

benzyl 4-oxo-1-piperidinecarboxylate

Downstream raw materials:

2-(4-methylsulfanyl-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid benzyl ester

2-(4-methylsulfanyl-phenyl)-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine

2-(4-methanesulfonyl-phenyl)-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine

2-(4-methanesulfonyl-phenyl)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid benzyl ester

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