Technology Process of 1,4-bis(trimethylsilylethynyl)-2,5-diethylbenzene
There total 3 articles about 1,4-bis(trimethylsilylethynyl)-2,5-diethylbenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diisopropylamine;
In
toluene;
at 20 ℃;
Inert atmosphere;
DOI:10.1016/j.tet.2010.05.016
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 99 percent / iodine; periodic acid; sulfuric acid / acetic acid; H2O / 24 h / 95 °C
2: 84 percent / copper(I) iodide; diisopropylethylamine / bis(triphenylphosphine)palladium(II) dichloride / tetrahydrofuran / Heating
With
copper(l) iodide; sulfuric acid; iodine; periodic acid; N-ethyl-N,N-diisopropylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; water; acetic acid;
2: Castro-Stephens/Sonogashira coupling;
DOI:10.1002/1521-3765(20011203)7:23<5118::AID-CHEM5118>3.0.CO;2-1
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 77 percent / aq. HCl; H2 / Pd/C / ethanol / 50 °C / 3102.97 Torr
2: 56 percent / I2; H5IO6*2H2O; H2SO4 / acetic acid; H2O / 22 h / 100 °C
3: 88 percent / Pd(PPh3)2Cl2; CuI; Huenig's base / tetrahydrofuran / 24 h / 20 °C
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; hydrogen; iodine; periodic acid; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; water; acetic acid;
3: Sonogashira coupling reaction;
DOI:10.5555/ol007036g
