2-bromomethyl-1-(2-chlorobenzyl)-2-methylaziridine

Base Information

• Chemical Name: 2-bromomethyl-1-(2-chlorobenzyl)-2-methylaziridine
• CAS No.: 1281964-01-9
• Molecular Formula: C₁₁H₁₃BrClN
• Molecular Weight: 274.588
• Mol file: 1281964-01-9.mol

Synonyms:2-bromomethyl-1-(2-chlorobenzyl)-2-methylaziridine

Chemical Property of 2-bromomethyl-1-(2-chlorobenzyl)-2-methylaziridine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-bromomethyl-1-(2-chlorobenzyl)-2-methylaziridine

There total 2 articles about 2-bromomethyl-1-(2-chlorobenzyl)-2-methylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C11H12Br2ClN (1281963-93-6) → 2-bromomethyl-1-(2-chlorobenzyl)-2-methylaziridine (1281964-01-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 36h;

DOI:10.1021/jo102555r

Reference yield:

2-CHLOROBENZYLAMINE (89-97-4) → 2-bromomethyl-1-(2-chlorobenzyl)-2-methylaziridine (1281964-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: titanium tetrachloride; triethylamine / diethyl ether / 4 h / 0 - 20 °C

2: sodium tetrahydroborate / methanol / 36 h / 0 - 20 °C

With sodium tetrahydroborate; titanium tetrachloride; triethylamine; In methanol; diethyl ether;

DOI:10.1021/jo102555r

Reference yield: 89.0%

methanol (67-56-1) + 2-bromomethyl-1-(2-chlorobenzyl)-2-methylaziridine (1281964-01-9) → 1-(2-chlorobenzyl)-3-methoxy-3-methylazetidine (1281964-03-1)

Guidance literature:

With sodium tetrahydroborate; at 0 ℃; for 48h; Reflux;

DOI:10.1021/jo102555r

upstream raw materials:

C₁₁H₁₂Br₂ClN

2-CHLOROBENZYLAMINE

Downstream raw materials:

1-(2-chlorobenzyl)-3-methoxy-3-methylazetidine