O-(chloroacetylcarbamoyl)fumagillol

Base Information

Chemical Name:O-(chloroacetylcarbamoyl)fumagillol
CAS No.:129298-91-5
Deprecated CAS:333999-83-0
Molecular Formula:C19H28ClNO6
Molecular Weight:401.887
Hs Code.:
European Community (EC) Number:663-348-8
NSC Number:642492
UNII:X47GR46481
DSSTox Substance ID:DTXSID0041141
Nikkaji Number:J458.810J
Wikidata:Q27097825
NCI Thesaurus Code:C1298
Pharos Ligand ID:A2D8P5CC68JH
Metabolomics Workbench ID:151755
ChEMBL ID:CHEMBL424278
Mol file:129298-91-5.mol

Synonyms:5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2,5)oct-6-yl(chloroacetyl) carbamate;AGM 1470;AGM-1470;AGM1470;caplostatin;O-(chloroacetylcarbamoyl)fumagillol;TNP 470;TNP-470;TNP470

Suppliers and Price of O-(chloroacetylcarbamoyl)fumagillol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TNP-470
10 mg
$ 160.00

Sigma-Aldrich
TNP-470
10mg
$ 200.00

Sigma-Aldrich
TNP-470 ≥98% (HPLC)
5mg
$ 195.00

Sigma-Aldrich
TNP-470 ≥98% (HPLC)
25mg
$ 758.00

Medical Isotopes, Inc.
TNP-470
100 mg
$ 1325.00

JR MediChem
TNP-470 96%
5g
$ 9980.00

JR MediChem
TNP-470 96%
500mg
$ 1698.00

JR MediChem
TNP-470 96%
25mg
$ 198.00

JR MediChem
TNP-470 96%
5mg
$ 68.00

ChemScene
TNP-470 >99.0%
5mg
$ 180.00

Total 15 raw suppliers

Chemical Property of O-(chloroacetylcarbamoyl)fumagillol

Chemical Property:

Refractive Index:1.535
PKA:7.19±0.46(Predicted)
PSA：89.69000
Density:1.26 g/cm³
LogP:2.94530
Storage Temp.:Store at -20°C
Solubility.:DMSO: >15mg/mL
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:401.1605153
Heavy Atom Count:27
Complexity:636

Purity/Quality:

98%,99%, ^*data from raw suppliers

TNP-470 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)NC(=O)CCl)OC)C
Isomeric SMILES:CC(=CC[C@@H]1[C@@](O1)(C)[C@H]2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)NC(=O)CCl)OC)C
Recent ClinicalTrials:A Phase I Study of TNP-470 in the Treatment of AIDS-Associated Kaposi's Sarcoma
Description TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.
Uses TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis. TNP-470 is a synthetic analog of Fumagillin (F862650); a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis and shows promise as both an anti-infective and antiangiogenic agent.

Technology Process of O-(chloroacetylcarbamoyl)fumagillol

There total 1 articles about O-(chloroacetylcarbamoyl)fumagillol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%