129299-06-5

Basic information

• Product Name: (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl carbamate
• Synonyms: 1-oxaspiro[2.5]octan-6-ol, 5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)oxiranyl]-, carbamate, (3R,4S,5S,6R)-
• CAS NO: 129299-06-5
• Molecular Formula: C₁₇H₂₇NO₅
• Molecular Weight: 325.4
• Mol File: 129299-06-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 462.9°C at 760 mmHg
• Flash Point: 180.4°C
• Density: 1.18g/cm³
• Vapor Pressure: 9.49E-09mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl carbamate(129299-06-5)
• EPA Substance Registry System: (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl carbamate(129299-06-5)

Safety Data

• Hazardous Substances Data: 129299-06-5(Hazardous Substances Data)

Usage

General Description

The chemical (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl carbamate is a complex organic compound with a unique molecular structure. It contains a carbamate functional group and a spiro ring system, which gives it distinct chemical properties. The presence of methoxy and oxiran groups suggests potential for biological activity and reactivity. (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl carbamate may have applications in drug development, organic synthesis, and medicinal chemistry due to its intricate structure and potential pharmacological properties. Its synthesis and chemical properties make it a valuable target for further research and potential applications in various scientific and industrial fields.

Upstream product

• 57260-73-8 N-BOC-1,2-diaminoethane 
• 129298-91-5 6-O-chloroacetylcarbamoylfumagillol 
• 35903-52-7 fumagillol 
• 129299-05-4 6-O-phenoxycarbonylfumagillol 

Downstream Products

• 129299-51-0 6-O-(N'-benzoylallophanoyl)fumagillol 

Relevant articles and documents

POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.