129299-06-5 Usage
Uses
Used in Drug Development:
(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl carbamate is used as a potential pharmaceutical agent for its possible biological activity and reactivity, which can be harnessed to develop new drugs with specific therapeutic effects.
Used in Organic Synthesis:
In the field of organic synthesis, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl carbamate serves as a key intermediate or building block in the synthesis of other complex organic molecules, leveraging its unique structural features.
Used in Medicinal Chemistry:
(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl carbamate is utilized in medicinal chemistry for its potential to contribute to the discovery of new therapeutic agents, given its intricate structure and pharmacological properties.
Used in Scientific Research:
In the scientific research industry, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl carbamate is used as a subject of study to explore its chemical properties, synthesis pathways, and potential applications, furthering the understanding of complex organic compounds and their role in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 129299-06-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,2,9 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 129299-06:
(8*1)+(7*2)+(6*9)+(5*2)+(4*9)+(3*9)+(2*0)+(1*6)=155
155 % 10 = 5
So 129299-06-5 is a valid CAS Registry Number.
129299-06-5Relevant academic research and scientific papers
POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF
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Paragraph 0228; 0229, (2017/09/25)
One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.
Chemical modification of fumagillin. I. 6-O-Acyl, 6-O-sulfonyl, 6-O-alkyl, and 6-O-(N-substituted-carbamoyl)fumagillols
Marui,Itoh,Kozai,Sudo,Kishimoto
, p. 96 - 101 (2007/10/02)
The hydroxy group of fumagillol (3), a degradation product of fumagillin (1), was acylated, sulfonylated, alkylated or carbamoylated, and the anti-angiogenic activity of the resulting products was examined. These compounds inhibited the angiogenesis induced by basic fibroblast growth factor in the rat corneal micropocket assay and the growth of vascular endothelial cells in vitro. Among them, compound 2 (AGM-1470) was found to show the most potent inhibitory effect on the growth of vascular endothelial cells and was selected from this series as a candidate for further development.
