(1’R,2S)-1-(2’-benzyloxy-1’-phenylethyl)-2-(2-[1,3]dioxolan-2-ylethyl)aziridine

Base Information

Chemical Name:(1’R,2S)-1-(2’-benzyloxy-1’-phenylethyl)-2-(2-[1,3]dioxolan-2-ylethyl)aziridine
CAS No.:1451214-33-7
Molecular Formula:C₂₂H₂₇NO₃
Molecular Weight:353.461
Hs Code.:

Synonyms:(1’R,2S)-1-(2’-benzyloxy-1’-phenylethyl)-2-(2-[1,3]dioxolan-2-ylethyl)aziridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1’R,2S)-1-(2’-benzyloxy-1’-phenylethyl)-2-(2-[1,3]dioxolan-2-ylethyl)aziridine

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Technology Process of (1’R,2S)-1-(2’-benzyloxy-1’-phenylethyl)-2-(2-[1,3]dioxolan-2-ylethyl)aziridine

There total 3 articles about (1’R,2S)-1-(2’-benzyloxy-1’-phenylethyl)-2-(2-[1,3]dioxolan-2-ylethyl)aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.9%

: C₂₁H₂₅NO₃

: 2181-42-2
trimethylsulphonium iodide

: 1451214-34-8
C₂₂H₂₇NO₃

: 1451214-33-7
(1’R,2S)-1-(2’-benzyloxy-1’-phenylethyl)-2-(2-[1,3]dioxolan-2-ylethyl)aziridine

Guidance literature:: trimethylsulphonium iodide; With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.333333h; Inert atmosphere;

C₂₁H₂₅NO₃; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h; diastereoselective reaction; Inert atmosphere;
DOI:10.3987/COM-12-S(N)26

Reference yield:

: 82962-18-3
3-([1,3]-dioxolan-2-yl)propanal

: 1451214-33-7
(1’R,2S)-1-(2’-benzyloxy-1’-phenylethyl)-2-(2-[1,3]dioxolan-2-ylethyl)aziridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / Molecular sieve

2.1: n-butyllithium; N,N,N,N,N,N-hexamethylphosphoric triamide / hexane; tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 0 °C / Inert atmosphere

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.3987/COM-12-S(N)26

Reference yield:

: 82962-18-3
3-([1,3]-dioxolan-2-yl)propanal

: 162237-91-4
(R)-1-phenyl-2-(phenylmethoxy)ethylamine

: 1451214-34-8
C₂₂H₂₇NO₃

: 1451214-33-7
(1’R,2S)-1-(2’-benzyloxy-1’-phenylethyl)-2-(2-[1,3]dioxolan-2-ylethyl)aziridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / Molecular sieve

2.1: n-butyllithium; N,N,N,N,N,N-hexamethylphosphoric triamide / hexane; tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 0 °C / Inert atmosphere

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.3987/COM-12-S(N)26