benzyl ((2R)-2-((1S)-2-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)carbamate

Base Information

Chemical Name:benzyl ((2R)-2-((1S)-2-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)carbamate
CAS No.:1428475-59-5
Molecular Formula:C₂₃H₂₉NO₄
Molecular Weight:383.488
Hs Code.:

Synonyms:benzyl ((2R)-2-((1S)-2-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)carbamate

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Chemical Property of benzyl ((2R)-2-((1S)-2-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)carbamate

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Technology Process of benzyl ((2R)-2-((1S)-2-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)carbamate

There total 6 articles about benzyl ((2R)-2-((1S)-2-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S)-2-((R)-2-amino-1-(4-methoxyphenyl)ethyl)cyclohexan-1-ol

: 501-53-1,94274-21-2
benzyl chloroformate

: 1428475-59-5
benzyl ((2R)-2-((1S)-2-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)carbamate

Guidance literature:: With triethylamine; at 20 ℃;
DOI:10.1016/j.tetlet.2013.02.029

Reference yield:

: (2S)-2-((R)-1-(4-methoxyphenyl)-2-nitroethyl)cyclohexan-1-ol

: 1428475-59-5
benzyl ((2R)-2-((1S)-2-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1.5 h / 0 °C / Inert atmosphere

2: triethylamine / 20 °C

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; triethylamine; In methanol;
DOI:10.1016/j.tetlet.2013.02.029

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1428475-59-5
benzyl ((2R)-2-((1S)-2-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium acetate; acetic acid / 3 h / Sonication

2: p-toluenesulfonic acid monohydrate; N¹,N¹-dimethyl-N²-(((S)-pyrrolidin-2-yl)methyl)ethane-1,2-diamine / N,N-dimethyl-formamide / 24 h / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; water / 2 h / 0 °C

4: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1.5 h / 0 °C / Inert atmosphere

5: triethylamine / 20 °C

With N¹,N¹-dimethyl-N²-(((S)-pyrrolidin-2-yl)methyl)ethane-1,2-diamine; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ammonium acetate; p-toluenesulfonic acid monohydrate; acetic acid; triethylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 2: |Michael Addition;
DOI:10.1016/j.tetlet.2013.02.029