(S)-2-((2R,3S,4R)-2,4-Bis-benzyloxy-3-methyl-pentanoylamino)-3-hydroxy-2-methyl-propionic acid benzyl ester

Base Information

Chemical Name:(S)-2-((2R,3S,4R)-2,4-Bis-benzyloxy-3-methyl-pentanoylamino)-3-hydroxy-2-methyl-propionic acid benzyl ester
CAS No.:357274-64-7
Molecular Formula:C₃₁H₃₇NO₆
Molecular Weight:519.638
Hs Code.:

Synonyms:(S)-2-((2R,3S,4R)-2,4-Bis-benzyloxy-3-methyl-pentanoylamino)-3-hydroxy-2-methyl-propionic acid benzyl ester

Suppliers and Price of (S)-2-((2R,3S,4R)-2,4-Bis-benzyloxy-3-methyl-pentanoylamino)-3-hydroxy-2-methyl-propionic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-((2R,3S,4R)-2,4-Bis-benzyloxy-3-methyl-pentanoylamino)-3-hydroxy-2-methyl-propionic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-((2R,3S,4R)-2,4-Bis-benzyloxy-3-methyl-pentanoylamino)-3-hydroxy-2-methyl-propionic acid benzyl ester

There total 11 articles about (S)-2-((2R,3S,4R)-2,4-Bis-benzyloxy-3-methyl-pentanoylamino)-3-hydroxy-2-methyl-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 180061-10-3
2-benzyloxycarbonyl-(S)-2-aminopropan-1-ol

: 221885-33-2
(2R,3S,4R)-2,4-dibenzyloxy-3-methylpentanoic acid

: 357274-64-7
(S)-2-((2R,3S,4R)-2,4-Bis-benzyloxy-3-methyl-pentanoylamino)-3-hydroxy-2-methyl-propionic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1016/S0040-4039(01)00649-9

Reference yield:

: 96-38-8
methylcyclopentadiene

: 357274-64-7
(S)-2-((2R,3S,4R)-2,4-Bis-benzyloxy-3-methyl-pentanoylamino)-3-hydroxy-2-methyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: O₂; rose bengal; AcONa / methanol / 1.33 h / -78 °C

1.2: 35 percent / (NH₂)2CS / methanol / 13 h / 20 °C

2.1: 94 percent / lipase AK / tetrahydrofuran / 7 h / 20 °C

3.1: 87 percent / Ag₂O; KI / toluene / 15.5 h / 20 °C

4.1: NaIO₄; KMnO₄; Na₂CO₃ / acetone; H₂O / 1 h / 20 °C

5.1: NMM / 1,2-dimethoxy-ethane / 3 h / 20 °C

6.1: NaBH₄ / 0.17 h / 0 °C

7.1: PhOCSCl; DMAP / CH₂Cl₂ / 4 h / 20 °C

7.2: 46 percent / AIBN; n-Bu₃SnH / toluene / 1 h / 75 °C

8.1: NaOH / methanol / 1 h / 20 °C

8.2: 85 percent / H(+) / methanol / pH 6 - 7

9.1: K₂CO₃ / acetone / 3.5 h / 20 °C

10.1: BF₃*Et₂O / cyclopentane / 2 h / 20 °C

11.1: K₂CO₃ / methanol / 2 h / Heating

12.1: 57 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; N-methylmorpholine; 1-hydroxybenzotriazole / dimethylformamide / 6 h / 20 °C

With 4-methyl-morpholine; dmap; sodium hydroxide; sodium tetrahydroborate; potassium permanganate; sodium periodate; lipase AK; boron trifluoride diethyl etherate; oxygen; sodium acetate; rose bengal; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; phenylcarbonochloridothioate; potassium iodide; silver(l) oxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; Cyclopentane; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/S0040-4039(01)00649-9

Reference yield:

: 221885-27-4
methyl (2R,3S,4R)-2-(benzyloxy)-4-hydroxy-3-methylpentanoate

: 357274-64-7
(S)-2-((2R,3S,4R)-2,4-Bis-benzyloxy-3-methyl-pentanoylamino)-3-hydroxy-2-methyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: BF₃*Et₂O / cyclopentane / 2 h / 20 °C

2: K₂CO₃ / methanol / 2 h / Heating

3: 57 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; N-methylmorpholine; 1-hydroxybenzotriazole / dimethylformamide / 6 h / 20 °C

With 4-methyl-morpholine; boron trifluoride diethyl etherate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; Cyclopentane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)00649-9