2-(4-methyl-3-pivalamidophenyl)imidazo[1,2-b]pyridazin-6-ylboronic acid

Base Information

Chemical Name:2-(4-methyl-3-pivalamidophenyl)imidazo[1,2-b]pyridazin-6-ylboronic acid
CAS No.:1383625-19-1
Molecular Formula:C₁₈H₂₁BN₄O₃
Molecular Weight:352.201
Hs Code.:

Synonyms:2-(4-methyl-3-pivalamidophenyl)imidazo[1,2-b]pyridazin-6-ylboronic acid

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Chemical Property of 2-(4-methyl-3-pivalamidophenyl)imidazo[1,2-b]pyridazin-6-ylboronic acid

Chemical Property:

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Technology Process of 2-(4-methyl-3-pivalamidophenyl)imidazo[1,2-b]pyridazin-6-ylboronic acid

There total 6 articles about 2-(4-methyl-3-pivalamidophenyl)imidazo[1,2-b]pyridazin-6-ylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383618-47-0
N-(5-(6-chloro-3-methylimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

: 73183-34-3
bis(pinacol)diborane

: 1383625-19-1
2-(4-methyl-3-pivalamidophenyl)imidazo[1,2-b]pyridazin-6-ylboronic acid

Guidance literature:: N-(5-(6-chloro-3-methylimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide; bis(pinacol)diborane; With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 90 ℃; for 16h;

With water; sodium hydroxide; for 1h;

With hydrogenchloride; In water; pH=5;

Reference yield:

: 5337-93-9
4'-methylpropiophenone

: 1383625-19-1
2-(4-methyl-3-pivalamidophenyl)imidazo[1,2-b]pyridazin-6-ylboronic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: nitric acid / 0 - 10 °C

2.1: bromine / dichloromethane / 20 °C

3.1: acetonitrile / 16 h / 80 °C

4.1: acetic acid; iron / ethanol; water / 6 h / 80 °C

5.1: pyridine / acetonitrile / 4 h / 20 °C

6.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 90 °C

6.2: 1 h

6.3: pH 5

With pyridine; bromine; nitric acid; potassium acetate; iron; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 50630-41-6
1-(4'-methyl-3'-nitrophenyl)-propane-1-one

: 1383625-19-1
2-(4-methyl-3-pivalamidophenyl)imidazo[1,2-b]pyridazin-6-ylboronic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / dichloromethane / 20 °C

2.1: acetonitrile / 16 h / 80 °C

3.1: acetic acid; iron / ethanol; water / 6 h / 80 °C

4.1: pyridine / acetonitrile / 4 h / 20 °C

5.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 90 °C

5.2: 1 h

5.3: pH 5

With pyridine; bromine; potassium acetate; iron; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;