4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulfonamide fumarate

Base Information

Chemical Name:4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulfonamide fumarate
CAS No.:766558-28-5
Molecular Formula:C₄H₄O₄*C₂₆H₄₂N₄O₅S
Molecular Weight:638.783
Hs Code.:

Synonyms:4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulfonamide fumarate

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Chemical Property of 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulfonamide fumarate

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Technology Process of 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulfonamide fumarate

There total 3 articles about 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulfonamide fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 195504-08-6
1-(N-Methyl-8-azabicyclo[3.2.1]oct-3-yl)-piperazine

: 766558-33-2
[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetic acid

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 766558-28-5
4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulfonamide fumarate

Guidance literature:: 1-(N-Methyl-8-azabicyclo[3.2.1]oct-3-yl)-piperazine; [2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetic acid; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

(2E)-but-2-enedioic acid;
DOI:10.1021/jm2016057

Reference yield:

: 766558-32-1
[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetic acid 1,1-dimethylethyl ester

: 766558-28-5
4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulfonamide fumarate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm2016057

Reference yield:

: 55661-08-0
4-methoxy-2,6-dimethylbenzenesulfonyl chloride

: 766558-28-5
4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1-piperazinyl]-2-oxoethoxy]ethyl]benzenesulfonamide fumarate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 15 h / 20 °C

2: tetrabutyl-ammonium chloride; sodium hydroxide / water; toluene / 0.5 h / 10 - 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

4: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; tetrabutyl-ammonium chloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2016057