{(6R,9aS)-6-[4-(2-methoxy-ethoxy)-2,3-dimethylphenyl]-octahydro-pyrido[1,2-a]pyrazin-2-yl}-(6-trifluoromethyl-pyridin-3-yl)-methanone

Base Information

Chemical Name:{(6R,9aS)-6-[4-(2-methoxy-ethoxy)-2,3-dimethylphenyl]-octahydro-pyrido[1,2-a]pyrazin-2-yl}-(6-trifluoromethyl-pyridin-3-yl)-methanone
CAS No.:873318-76-4
Molecular Formula:C₂₆H₃₂F₃N₃O₃
Molecular Weight:491.554
Hs Code.:

Synonyms:{(6R,9aS)-6-[4-(2-methoxy-ethoxy)-2,3-dimethylphenyl]-octahydro-pyrido[1,2-a]pyrazin-2-yl}-(6-trifluoromethyl-pyridin-3-yl)-methanone

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Chemical Property of {(6R,9aS)-6-[4-(2-methoxy-ethoxy)-2,3-dimethylphenyl]-octahydro-pyrido[1,2-a]pyrazin-2-yl}-(6-trifluoromethyl-pyridin-3-yl)-methanone

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Technology Process of {(6R,9aS)-6-[4-(2-methoxy-ethoxy)-2,3-dimethylphenyl]-octahydro-pyrido[1,2-a]pyrazin-2-yl}-(6-trifluoromethyl-pyridin-3-yl)-methanone

There total 12 articles about {(6R,9aS)-6-[4-(2-methoxy-ethoxy)-2,3-dimethylphenyl]-octahydro-pyrido[1,2-a]pyrazin-2-yl}-(6-trifluoromethyl-pyridin-3-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869794-18-3
[(6R,9aS)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone

: 6482-24-2
2-Bromoethyl methyl ether

: 873318-76-4
{(6R,9aS)-6-[4-(2-methoxy-ethoxy)-2,3-dimethylphenyl]-octahydro-pyrido[1,2-a]pyrazin-2-yl}-(6-trifluoromethyl-pyridin-3-yl)-methanone

Guidance literature:: With potassium hydroxide; In acetonitrile; at 60 ℃; for 20.5h;

Reference yield:

: 477220-37-4
(S)-4-Benzyl-2-(2-oxopropyl)-piperazine-1-carboxylic acid tert-butyl ester

: 873318-76-4
{(6R,9aS)-6-[4-(2-methoxy-ethoxy)-2,3-dimethylphenyl]-octahydro-pyrido[1,2-a]pyrazin-2-yl}-(6-trifluoromethyl-pyridin-3-yl)-methanone

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium chloride / tetrahydrofuran / 0.67 h / 20 °C

1.2: 22 h / 0 - 20 °C

2.1: hydrogenchloride / methanol; water / 3 h / 60 °C

3.1: ammonium acetate / methanol; water / 16.5 h / 20 - 60 °C

4.1: tetrahydrofuran; methanol / 20 h / 20 °C

5.1: zinc trifluoromethanesulfonate; sodium cyanoborohydride / methanol / 6 h / 65 °C

5.2: 0.5 h

6.1: ammonium formate / 20% Pd(OH)2 on carbon / 2 h / Heating / reflux

7.1: dmap; triethylamine / dichloromethane / 18 h / 20 °C

8.1: hydrogenchloride / diethyl ether; dichloromethane / 0.17 h

8.2: 18.33 h / -70 - 20 °C

8.3: 0.5 h / 0 °C

9.1: potassium hydroxide / acetonitrile / 20.5 h / 60 °C

With hydrogenchloride; dmap; potassium hydroxide; ammonium acetate; ammonium formate; zinc trifluoromethanesulfonate; sodium cyanoborohydride; triethylamine; lithium chloride; 20% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile; 1.1: Aldol Condensation / 7.1: Schotten-Baumann Reaction;

Reference yield:

: 869794-14-9
(E)-1-((S)-4-Benzyl-piperazin-2-yl)-4-(4-methoxy-2,3-dimethylphenyl)-but-3-en-2-one

: 873318-76-4
{(6R,9aS)-6-[4-(2-methoxy-ethoxy)-2,3-dimethylphenyl]-octahydro-pyrido[1,2-a]pyrazin-2-yl}-(6-trifluoromethyl-pyridin-3-yl)-methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium acetate / methanol; water / 16.5 h / 20 - 60 °C

2.1: tetrahydrofuran; methanol / 20 h / 20 °C

3.1: zinc trifluoromethanesulfonate; sodium cyanoborohydride / methanol / 6 h / 65 °C

3.2: 0.5 h

4.1: ammonium formate / 20% Pd(OH)2 on carbon / 2 h / Heating / reflux

5.1: dmap; triethylamine / dichloromethane / 18 h / 20 °C

6.1: hydrogenchloride / diethyl ether; dichloromethane / 0.17 h

6.2: 18.33 h / -70 - 20 °C

6.3: 0.5 h / 0 °C

7.1: potassium hydroxide / acetonitrile / 20.5 h / 60 °C

With hydrogenchloride; dmap; potassium hydroxide; ammonium acetate; ammonium formate; zinc trifluoromethanesulfonate; sodium cyanoborohydride; triethylamine; 20% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile; 5.1: Schotten-Baumann Reaction;