[(6R,9aS)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone

Base Information

Chemical Name:[(6R,9aS)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone
CAS No.:869794-18-3
Molecular Formula:C₂₃H₂₆F₃N₃O₂
Molecular Weight:433.474
Hs Code.:

Synonyms:[(6R,9aS)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone

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Chemical Property of [(6R,9aS)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone

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Technology Process of [(6R,9aS)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone

There total 13 articles about [(6R,9aS)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(6R,9aS)-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone

: 869794-18-3
[(6R,9aS)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone

Guidance literature:: [(6R,9aS)-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone; With hydrogenchloride; In diethyl ether; dichloromethane; for 0.166667h;

With boron tribromide; In dichloromethane; at -70 - 20 ℃; for 18.33h; Cooling with dry ice/isopropanol;

With sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃; for 0.5h;

Reference yield:

: 869794-14-9
(E)-1-((S)-4-Benzyl-piperazin-2-yl)-4-(4-methoxy-2,3-dimethylphenyl)-but-3-en-2-one

: 869794-18-3
[(6R,9aS)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate / methanol; water / 16.5 h / 20 - 60 °C

2.1: tetrahydrofuran; methanol / 20.5 h / 20 °C

3.1: zinc trifluoromethanesulfonate; sodium cyanoborohydride / tetrahydrofuran; methanol / 5.5 h / 65 °C

3.2: 0.5 h

4.1: ammonium formate / palladium(II) hydroxide/carbon / methanol / 2 h / Heating / reflux

5.1: dmap; triethylamine / dichloromethane / 18 h / 20 °C

6.1: hydrogenchloride / diethyl ether; dichloromethane / 0.17 h

6.2: 18.33 h / -70 - 20 °C / Cooling with dry ice/isopropanol

6.3: 0.5 h / 0 °C

With hydrogenchloride; dmap; ammonium acetate; ammonium formate; zinc trifluoromethanesulfonate; sodium cyanoborohydride; triethylamine; palladium(II) hydroxide/carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;

Reference yield:

: 869794-16-1
(6R,9aS)-2-benzyl-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazine

: 869794-18-3
[(6R,9aS)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium formate / palladium(II) hydroxide/carbon / methanol / 2 h / Heating / reflux

2.1: dmap; triethylamine / dichloromethane / 18 h / 20 °C

3.1: hydrogenchloride / diethyl ether; dichloromethane / 0.17 h

3.2: 18.33 h / -70 - 20 °C / Cooling with dry ice/isopropanol

3.3: 0.5 h / 0 °C

With hydrogenchloride; dmap; ammonium formate; triethylamine; palladium(II) hydroxide/carbon; In methanol; diethyl ether; dichloromethane;